Literature DB >> 10973278

BCL-6 regulates chemokine gene transcription in macrophages.

L M Toney1, G Cattoretti, J A Graf, T Merghoub, P P Pandolfi, R Dalla-Favera, B H Ye, A L Dent.   

Abstract

The transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the mechanism for the T helper cell subset 2 (TH2)-type inflammation that occurs in BCL-6-/- mice. Using chimeric mice we found that the TH2-type inflammation is dependent upon nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of TH2-type inflammation by BCL-6 and link TH2 differentiation to innate immunity.

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Year:  2000        PMID： 10973278     DOI： 10.1038/79749

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  68 in total

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2.  C5a-induced gene expression in human umbilical vein endothelial cells.

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Journal:  Am J Pathol       Date:  2004-03       Impact factor: 4.307

3.  Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis.

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Review 4.  Common mechanisms for the regulation of B cell differentiation and transformation by the transcriptional repressor protein BCL-6.

Authors:  Saritha Kusam; Alexander Dent
Journal:  Immunol Res       Date:  2007       Impact factor: 2.829

5.  Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma.

Authors:  J Iqbal; T C Greiner; K Patel; B J Dave; L Smith; J Ji; G Wright; W G Sanger; D L Pickering; S Jain; D E Horsman; Y Shen; K Fu; D D Weisenburger; C P Hans; E Campo; R D Gascoyne; A Rosenwald; E S Jaffe; J Delabie; L Rimsza; G Ott; H K Müller-Hermelink; J M Connors; J M Vose; T McKeithan; L M Staudt; W C Chan
Journal:  Leukemia       Date:  2007-07-12       Impact factor: 11.528

Review 6.  B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma.

Authors:  Weimin Ci; Jose M Polo; Ari Melnick
Journal:  Curr Opin Hematol       Date:  2008-07       Impact factor: 3.284

7.  The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression.

Authors:  Jon E Ramsey; Joseph D Fontes
Journal:  Mol Immunol       Date:  2013-08-14       Impact factor: 4.407

8.  A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.

Authors:  Melanie S Vacchio; Thomas Ciucci; Yayi Gao; Masashi Watanabe; Mariah Balmaceno-Criss; Mitchell T McGinty; Allan Huang; Qi Xiao; Cameron McConkey; Yongmei Zhao; Jyoti Shetty; Bao Tran; Marion Pepper; Golnaz Vahedi; Marc K Jenkins; Dorian B McGavern; Rémy Bosselut
Journal:  Immunity       Date:  2019-08-15       Impact factor: 31.745

Review 9.  The genomic landscapes of inflammation.

Authors:  Gioacchino Natoli; Serena Ghisletti; Iros Barozzi
Journal:  Genes Dev       Date:  2011-01-15       Impact factor: 11.361

10.  AMPKα2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6.

Authors:  Brendan Gongol; Traci Marin; I-Chen Peng; Brian Woo; Marcy Martin; Stephanie King; Wei Sun; David A Johnson; Shu Chien; John Y-J Shyy
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-04       Impact factor: 11.205
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