Literature DB >> 10973052

On the conservation of protein sequences in evolution.

B Kisters-Woike1, C Vangierdegom, B Müller-Hill.   

Abstract

The amino acid sequences of enzymes like alcohol dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase are strongly conserved across all phyla. We suggest that the amino acid conservation of such enzymes might be a result of the fact that they function as part of a multi-enzyme complex. The specific interactions between the proteins involved would hinder evolutionary change of their surfaces.

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Year:  2000        PMID： 10973052     DOI： 10.1016/s0968-0004(00)01631-5

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


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3.  Inhibition of a Zn(II)-containing enzyme, alcohol dehydrogenase, by anticancer antibiotics, mithramycin and chromomycin A3.

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4.  A Multi-scale Computational Platform to Mechanistically Assess the Effect of Genetic Variation on Drug Responses in Human Erythrocyte Metabolism.

Authors:  Nathan Mih; Elizabeth Brunk; Aarash Bordbar; Bernhard O Palsson
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  4 in total

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