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Literature DB >> 10970401

Hepatitis C virus core mutations reduce the sensitivity of a fluorescence enzyme immunoassay.

H Tokita¹, G R Kaufmann, M Matsubayashi, I Okuda, T Tanaka, H Harada, M Mukaide, K Suzuki, D A Cooper.

Abstract

Four of 107 samples obtained from hepatitis C virus (HCV) carriers showed lower HCV core antigen levels in a fluorescence enzyme immunoassay (FEIA) than expected from corresponding HCV RNA levels. Nucleotide sequencing revealed a mutation in the HCV core region (Thr49Pro) that appears to have reduced the FEIA sensitivity.

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Year: 2000 PMID： 10970401 PMCID： PMC87404

Source DB: PubMed Journal: J Clin Microbiol ISSN： 0095-1137 Impact factor: 5.948

15 in total

1. Epidemiology of hepatitis C in the United States.

Authors: I Williams
Journal: Am J Med Date: 1999-12-27 Impact factor: 4.965

2. Quantification of serum hepatitis C virus core protein level in patients chronically infected with different hepatitis C virus genotypes.

Authors: E Orito; M Mizokami; T Tanaka; J Y Lau; K Suzuki; M Yamauchi; Y Ohta; A Hasegawa; S Tanaka; M Kohara
Journal: Gut Date: 1996-12 Impact factor: 23.059

3. Quantitative assays for hepatitis C virus in serum as predictors of the long-term response to interferon.

Authors: Y Shiratori; N Kato; O Yokosuka; E Hashimoto; N Hayashi; A Nakamura; M Asada; H Kuroda; H Ohkubo; Y Arakawa; A Iwama; M Omata
Journal: J Hepatol Date: 1997-09 Impact factor: 25.083

4. Determination of serum hepatitis C virus (HCV) core protein using a novel approach for quantitative evaluation of HCV viraemia in anti-HCV-positive patients.

Authors: F Komatsu; K Takasaki
Journal: Liver Date: 1999-10

5. New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a.

Authors: O Ohno; M Mizokami; R R Wu; M G Saleh; K Ohba; E Orito; M Mukaide; R Williams; J Y Lau
Journal: J Clin Microbiol Date: 1997-01 Impact factor: 5.948

6. Genotype dependence of hepatitis C virus load measurement in commercially available quantitative assays.

Authors: J Mellor; A Hawkins; P Simmonds
Journal: J Clin Microbiol Date: 1999-08 Impact factor: 5.948

7. Simple fluorescent enzyme immunoassay for detection and quantification of hepatitis C viremia.

Authors: T Tanaka; J Y Lau; M Mizokami; E Orito; E Tanaka; K Kiyosawa; K Yasui; Y Ohta; A Hasegawa; S Tanaka
Journal: J Hepatol Date: 1995-12 Impact factor: 25.083

8. Sequence analysis of the core gene of 14 hepatitis C virus genotypes.

Authors: J Bukh; R H Purcell; R H Miller
Journal: Proc Natl Acad Sci U S A Date: 1994-08-16 Impact factor: 11.205

9. The entire nucleotide sequences of three hepatitis C virus isolates in genetic groups 7-9 and comparison with those in the other eight genetic groups.

Authors: H Tokita; H Okamoto; H Iizuka; J Kishimoto; F Tsuda; Y Miyakawa; M Mayumi
Journal: J Gen Virol Date: 1998-08 Impact factor: 3.891