Literature DB >> 10970025

Proliferative activity and characteristics of the structural-functional organization of the chromosomes in cells of the developing brain, related to the genetically determined excitability of the nervous system in rats.

N A Dyuzhikova1, N V Shiryaeva, A I Vaido, V V Vshivtseva, N G Lopatina, Y I Levkovich.   

Abstract

This report describes the results of a comparative genetic analysis of the proliferation activity, level of chromosomal aberrations, and the state of interphase chromatin in nerve cells from the developing brains of rat embryos from lines with nervous systems of different excitation thresholds. A relationship between the basal level of nervous system excitability and these cytogenetic characteristics was found. Higher values were seen in embryos of the high-threshold line VP1, as compared with the low-threshold line NP1. The role of the cytogenetic characteristics of the embryo brain in the processes of CNS development and function are discussed in relation to the genetically determined level of nervous system excitability.

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Year:  2000        PMID： 10970025     DOI： 10.1007/bf02471784

Source DB:  PubMed          Journal:  Neurosci Behav Physiol        ISSN： 0097-0549


  13 in total

1.  A colchicine, hypotonic citrate, squash sequence for mammalian chromosomes.

Authors:  C E FORD; J L HAMERTON
Journal:  Stain Technol       Date:  1956-11

2.  [The effect of temperature on the 3-dimensional organization of polytene chromosomes in Drosophila mutants with altered calmodulin functions].

Authors:  A V Medvedeva; E V Savvateeva
Journal:  Dokl Akad Nauk SSSR       Date:  1991

3.  [The effect of ts mutations in the agnostic gene controlling calmodulin functions and learning capacity on the ectopic conjugation of polytene chromosomes in Drosophila].

Authors:  A V Medvedeva; E V Savvateeva
Journal:  Dokl Akad Nauk SSSR       Date:  1991

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Authors:  L I Lebedeva; S V Skorova; E M Akhmamet'eva
Journal:  Genetika       Date:  1993-11

5.  [The organizational characteristics of the Drosophila genome in mutants with altered second-messenger metabolism and with learning ability].

Authors:  A V Medvedeva; E V Tokmacheva; E V Savvateeva; V S Kornitskiĭ
Journal:  Fiziol Zh Im I M Sechenova       Date:  1995-08

Review 6.  Nuclear organization and gene expression.

Authors:  D L Spector
Journal:  Exp Cell Res       Date:  1996-12-15       Impact factor: 3.905

7.  [Frequency of chromosome aberrations induced by a single exposure to stress in rats selected for excitability of the nervous system].

Authors:  N A Diuzhiova; N V Bykovskaia; A I Vaĭdo; N V Shiriaeva; N G Lopatina; P Ia Shvartsman
Journal:  Genetika       Date:  1996-06

8.  Behavioral effects of temperature sensitive mutations affecting metabolism of cAMP in Drosophila melanogaster.

Authors:  E V Savvateeva; N G Kamyshev
Journal:  Pharmacol Biochem Behav       Date:  1981-05       Impact factor: 3.533

9.  [The mitotic activity of the cells in the head neural ganglion in larvae of the Drosophila ts mutant with an altered capacity for learning and augmented calmodulin activation properties].

Authors:  E V Tokmacheva
Journal:  Zh Vyssh Nerv Deiat Im I P Pavlova       Date:  1995 May-Jun       Impact factor: 0.437

10.  [Role of heat-shock proteins in the recovery of mitotic chromosome damage induced by high temperature in Drosophila melanogaster].

Authors:  L A Mamon; Iu A Kutskova
Journal:  Genetika       Date:  1993-04
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