| Literature DB >> 10969982 |
S J Gregson1, P W Howard, K E Corcoran, S Barcella, M M Yasin, A A Hurst, T C Jenkins, L R Kelland, D E Thurston.
Abstract
A series of novel C2-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) has been synthesised via a versatile pro-C2 ketone precursor. C2-exo-unsaturation enhances both DNA-binding reactivity and in vitro cytotoxic potency.Entities:
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Year: 2000 PMID： 10969982 DOI： 10.1016/s0960-894x(00)00351-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823