BACKGROUND: The immediate and intermediate-term neurodevelopmental outcome in infants undergoing open heart procedures using deep hypothermic cardiopulmonary bypass was assessed prospectively. METHODS: One hundred consecutive infants (age 2 to 174 days) were operated on using either deep hypothermic bypass only (group A, n = 28), or with associated circulatory arrest (group B, n = 72). Early neurological outcome was recorded. Survivors underwent mental development evaluation after 31 to 55 months. Fifty other children of similar demographic profile but without heart disease were also tested as controls. RESULTS: In group A, there were two neurological deaths. In group B, 5 patients had clinical seizures, 1 had monoparesis and 1 had hyperkinetic syndrome with decreased attention span. Mean mental performance quotient was 90.0+/-8.2 in group A, and 89.1+/-6.8 in group B, (group A vs. B, p = 0.60). Mean mental performance quotient in the control group was 101.4+/-8.4, which was significantly higher than the patient population (p << 0.001). No correlation was found between duration of circulatory arrest and postoperative mental performance quotient. CONCLUSIONS: There was significant retardation of mental development in infants operated with deep hypothermic cardiopulmonary bypass. However, use of total circulatory arrest and its duration did not affect clinical outcome up to preschool age.
BACKGROUND: The immediate and intermediate-term neurodevelopmental outcome in infants undergoing open heart procedures using deep hypothermic cardiopulmonary bypass was assessed prospectively. METHODS: One hundred consecutive infants (age 2 to 174 days) were operated on using either deep hypothermic bypass only (group A, n = 28), or with associated circulatory arrest (group B, n = 72). Early neurological outcome was recorded. Survivors underwent mental development evaluation after 31 to 55 months. Fifty other children of similar demographic profile but without heart disease were also tested as controls. RESULTS: In group A, there were two neurological deaths. In group B, 5 patients had clinical seizures, 1 had monoparesis and 1 had hyperkinetic syndrome with decreased attention span. Mean mental performance quotient was 90.0+/-8.2 in group A, and 89.1+/-6.8 in group B, (group A vs. B, p = 0.60). Mean mental performance quotient in the control group was 101.4+/-8.4, which was significantly higher than the patient population (p << 0.001). No correlation was found between duration of circulatory arrest and postoperative mental performance quotient. CONCLUSIONS: There was significant retardation of mental development in infants operated with deep hypothermic cardiopulmonary bypass. However, use of total circulatory arrest and its duration did not affect clinical outcome up to preschool age.
Authors: Stephanie Fuller; Ramakrishnan Rajagopalan; Gail P Jarvik; Marsha Gerdes; Judy Bernbaum; Gil Wernovsky; Robert R Clancy; Cynthia Solot; Susan C Nicolson; Thomas L Spray; J William Gaynor Journal: Ann Thorac Surg Date: 2010-12 Impact factor: 4.330
Authors: I Sook Park; S Young Yoon; J Yeon Min; Y Hwue Kim; J Kok Ko; K Soo Kim; D Man Seo; J Hee Lee Journal: Pediatr Cardiol Date: 2006-08-01 Impact factor: 1.655
Authors: C G McCusker; N N Doherty; B Molloy; F Casey; N Rooney; C Mulholland; A Sands; B Craig; M Stewart Journal: Arch Dis Child Date: 2006-10-09 Impact factor: 3.791
Authors: M Rosario Porcayo-Mercado; Gloria A Otero-Ojeda; F Bernardo Pliego-Rivero; Dalia M Aguirre-Pérez; Josefina Ricardo-Garcell Journal: J Clin Psychol Med Settings Date: 2013-03