| Literature DB >> 10968511 |
M De las Heras1, S H Barsky, P Hasleton, M Wagner, E Larson, J Egan, A Ortin, J A Gimenez-Mas, M Palmarini, J M Sharp.
Abstract
Human bronchioloalveolar carcinoma (BAC) is a lung cancer, morphologically similar to an endemic contagious lung neoplasm of sheep called sheep pulmonary adenomatosis (SPA) or jaagsiekte. SPA is caused by an exogenous type B/D retrovirus (jaagsiekte sheep retrovirus (JSRV)), which prompted the present study to obtain evidence of a retrovirus in BAC. A panel of 249 human lung tumours, 21 nontumour lung lesions, four normal lung tissues, 23 adenocarcinomas from other organs and a cell line expressing a human endogenous retrovirus protein was examined immunohistochemically using a rabbit antiserum directed against the JSRV capsid protein. Specific staining was detected only in the cytoplasm of recognizably neoplastic cells in the pulmonary alveoli of 39 of 129 (30%) BACs, 17 of 65 (26%) lung adenocarcinomas and two of seven large cell carcinomas. The remaining samples were negative. These results support the hypothesis that some human pulmonary tumours may be associated with a jaagsiekte sheep retrovirus-related retrovirus, warranting further studies.Entities:
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Year: 2000 PMID： 10968511 DOI： 10.1034/j.1399-3003.2000.16b23.x
Source DB: PubMed Journal: Eur Respir J ISSN： 0903-1936 Impact factor: 16.671