Literature DB >> 10968268

Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series.

B Bonnet1, D Soullez, S Girault, L Maes, V Landry, E Davioud-Charvet, C Sergheraert.   

Abstract

A series of symmetrically substituted 1,4-bis(3-aminopropyl)piperazines was synthesized and tested towards trypanothione reductase and for its in vitro trypanocidal potency. The most trypanocidal amongst them was found to be totally inactive towards the enzyme and thus constitutes a lead structure for the identification of new potential Trypanosoma cruzi target(s).

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Year:  2000        PMID： 10968268     DOI： 10.1016/s0968-0896(99)00268-0

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

1.  Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization.

Authors:  Jaimeen D Majmudar; Heather B Hodges-Loaiza; Kalub Hahne; James L Donelson; Jiao Song; Liza Shrestha; Marietta L Harrison; Christine A Hrycyna; Richard A Gibbs
Journal:  Bioorg Med Chem       Date:  2011-11-06       Impact factor: 3.641

2.  Application of linear discriminant analysis in the virtual screening of antichagasic drugs through trypanothione reductase inhibition.

Authors:  Julián J Prieto; Alan Talevi; Luis E Bruno-Blanch
Journal:  Mol Divers       Date:  2006-09-21       Impact factor: 2.943

Review 3.  Mini review on tricyclic compounds as an inhibitor of trypanothione reductase.

Authors:  Suresh Kumar; Md Rahmat Ali; Sandhya Bawa
Journal:  J Pharm Bioallied Sci       Date:  2014-10

4.  Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.

Authors:  John L Richardson; Isabelle R E Nett; Deuan C Jones; Mohamed H Abdille; Ian H Gilbert; Alan H Fairlamb
Journal:  ChemMedChem       Date:  2009-08       Impact factor: 3.466
  4 in total

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