Literature DB >> 10967310

Modulation of K(+)-induced synaptosomal calcium influx by gabapentin.

W P Meder1, D J Dooley.   

Abstract

Gabapentin, a drug useful in several neurological and psychiatric disorders, decreased K(+) (15 mM)-induced [Ca(2+)](i) increase in Fura-PE3-loaded rat neocortical synaptosomes (IC(50)=9.7 microM; submaximal inhibition of 28.6%). This effect may indicate a selective modulation of presynaptic Ca(2+) influx in response to depolarizing (pathological) conditions causing excessive neurotransmitter release.

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Year:  2000        PMID： 10967310     DOI： 10.1016/s0006-8993(00)02610-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  5 in total

1.  Nerve injury-induced calcium channel alpha-2-delta-1 protein dysregulation leads to increased pre-synaptic excitatory input into deep dorsal horn neurons and neuropathic allodynia.

Authors:  C Zhou; Z D Luo
Journal:  Eur J Pain       Date:  2015-02-17       Impact factor: 3.931

Review 2.  Molecular pharmacology of high voltage-activated calcium channels.

Authors:  Clinton J Doering; Gerald W Zamponi
Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

3.  A comparison of Ca2+ channel blocking mode between gabapentin and verapamil: implication for protection against hypoxic injury in rat cerebrocortical slices.

Authors:  Michiko Oka; Yoshinori Itoh; Miyuki Wada; Akira Yamamoto; Takuya Fujita
Journal:  Br J Pharmacol       Date:  2003-05       Impact factor: 8.739

4.  Gabapentin blocks L-type and P/Q-type Ca2+ channels involved in depolarization-stimulated nitric oxide synthase activity in primary cultures of neurons from mouse cerebral cortex.

Authors:  Michiko Oka; Yoshinori Itoh; Miyuki Wada; Akira Yamamoto; Takuya Fujita
Journal:  Pharm Res       Date:  2003-06       Impact factor: 4.200

5.  Gabapentin potentiates sensitivity to the interoceptive effects of alcohol and increases alcohol self-administration in rats.

Authors:  Joyce Besheer; Suzanne Frisbee; Patrick A Randall; Anel A Jaramillo; Maria Masciello
Journal:  Neuropharmacology       Date:  2015-09-28       Impact factor: 5.250
  5 in total

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