Literature DB >> 10966986

Apoptosis of testicular germ cells induced by exogenous glucocorticoid in rats.

H Yazawa1, I Sasagawa, T Nakada.   

Abstract

The influence of exogenous glucocorticoid, dexamethasone (Dex), on testicular germ cell apoptosis was investigated in rats. The percentages of apoptotic tubules and apoptotic germ cells in the Dex-treated group of rats were about seven-fold and 10-fold higher respectively than in either the control group, or in rats treated with glucocorticoid receptor agonist (GR-A), or in rats treated with both Dex and GR-A. These results suggest that, in rats, apoptosis of testicular germ cells is mediated by glucocorticoid receptors.

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Year:  2000        PMID： 10966986     DOI： 10.1093/humrep/15.9.1917

Source DB:  PubMed          Journal:  Hum Reprod        ISSN： 0268-1161            Impact factor:   6.918


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