P T Finger1. 1. New York Eye Cancer Centre, New York Eye and Ear Infirmary, and Department of Ophthalmology, New York University School of Medicine, New York City 10021, USA. pfinger@eyecancer.com
Abstract
AIM: To examine how tumour location affects ocular morbidity after ophthalmic plaque radiotherapy for uveal melanoma. METHODS: 69 eyes were irradiated and followed for a mean 42 months. There were 23 anterior uveal melanomas and 46 were posterior to the equator. Anterior and posterior tumours had similar basal dimensions. Their mean apical heights were 4.8 mm (anterior) and 3.5 mm (posterior) which received a mean 88 Gy and 83.4 Gy respectively. RESULTS: Only one patient (4%) plaqued for an anterior uveal melanoma developed secondary retinopathy (cystoid macular oedema). In contrast, 24 (52%) of the posterior choroidal melanoma patients developed retinopathy (p value <0.0001). Cataract developed in 18 (86%) eyes with phakic anterior tumour compared with seven (17%) eyes with posterior tumours (p value <0.0000). No posterior nasal tumours lost more than two lines of vision though 45% developed retinopathy. CONCLUSION: While plaque radiation of anterior melanomas is more likely to cause reversible vision loss secondary to cataract, treatment of posterior tumours is more likely to be associated with irreversible loss because of retinopathy. Nasal location is also protective against severe loss of vision.
AIM: To examine how tumour location affects ocular morbidity after ophthalmic plaque radiotherapy for uveal melanoma. METHODS: 69 eyes were irradiated and followed for a mean 42 months. There were 23 anterior uveal melanomas and 46 were posterior to the equator. Anterior and posterior tumours had similar basal dimensions. Their mean apical heights were 4.8 mm (anterior) and 3.5 mm (posterior) which received a mean 88 Gy and 83.4 Gy respectively. RESULTS: Only one patient (4%) plaqued for an anterior uveal melanoma developed secondary retinopathy (cystoid macular oedema). In contrast, 24 (52%) of the posterior choroidal melanomapatients developed retinopathy (p value <0.0001). Cataract developed in 18 (86%) eyes with phakic anterior tumour compared with seven (17%) eyes with posterior tumours (p value <0.0000). No posterior nasal tumours lost more than two lines of vision though 45% developed retinopathy. CONCLUSION: While plaque radiation of anterior melanomas is more likely to cause reversible vision loss secondary to cataract, treatment of posterior tumours is more likely to be associated with irreversible loss because of retinopathy. Nasal location is also protective against severe loss of vision.
Authors: P T Finger; T K Ho; D M Fastenberg; R A Hyman; E M Stroh; S Packer; H D Perry Journal: Invest Ophthalmol Vis Sci Date: 1990-09 Impact factor: 4.799
Authors: Mark J Rivard; Sou-Tung Chiu-Tsao; Paul T Finger; Ali S Meigooni; Christopher S Melhus; Firas Mourtada; Mary E Napolitano; D W O Rogers; Rowan M Thomson; Ravinder Nath Journal: Med Phys Date: 2011-01 Impact factor: 4.071
Authors: Y M Bartlema; J A Oosterhuis; J G Journée-De Korver; R E Tjho-Heslinga; J E E Keunen Journal: Br J Ophthalmol Date: 2003-11 Impact factor: 4.638