Literature DB >> 10966866

MAGUK proteins: structure and role in the tight junction.

L González-Mariscal1, A Betanzos, A Avila-Flores.   

Abstract

ZO-1, ZO-2 and ZO-3 are tight junction (TJ)-associated proteins that belong to the MAGUK family. In addition to the presence of the characteristic MAGUK modules (PDZ, SH3 and GK), ZOs have a distinctive carboxyl terminal with splicing domains, acidic- and proline-rich regions. The modular organization of these proteins allows them to function as scaffolds, which associate to transmembrane TJ proteins, the cytoskeleton and signal transduction molecules. ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression. Copyright 2000 Academic Press.

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Year:  2000        PMID： 10966866     DOI： 10.1006/scdb.2000.0178

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


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