OBJECTIVE: To analyse the repair of lesions of articular cartilage with periosteum-free implants and follow-up at 6 months. DESIGN: Thirty-six New Zealand rabbits, 4-6 weeks old, were used. Full-thickness articular cartilage defects in the medial femoral condyle were created. Spontaneous evolution occurred in 18 animals; the other 18 animals were treated with a free autogenous periosteal tibial implant fixed with Tissucol. Animals were killed in groups of six at 8, 12 and 24 weeks. Macroscopic, histologic and histochemical results were evaluated and analysed statistically using the Mann-Whitney U-test. RESULTS: The spontaneous evolution of the lesion did not lead to complete repair in any case. The periosteum-free implant provided complete repair of the lesion and statistically significant restoration of the articular surface. CONCLUSIONS: In the rabbit, this study confirms the incomplete spontaneous repair of articular cartilage and the chondrogenic potential of tibial periosteum-free implants, with long-term maintenance of the macroscopic, histologic and histochemical characteristics of neo-cartilage. This raises the possibility of its use as an alternative method in the repair of circumscribed osteochondral lesions in young patients. Copyright 2000 OsteoArthritis Research Society International.
OBJECTIVE: To analyse the repair of lesions of articular cartilage with periosteum-free implants and follow-up at 6 months. DESIGN: Thirty-six New Zealand rabbits, 4-6 weeks old, were used. Full-thickness articular cartilage defects in the medial femoral condyle were created. Spontaneous evolution occurred in 18 animals; the other 18 animals were treated with a free autogenous periosteal tibial implant fixed with Tissucol. Animals were killed in groups of six at 8, 12 and 24 weeks. Macroscopic, histologic and histochemical results were evaluated and analysed statistically using the Mann-Whitney U-test. RESULTS: The spontaneous evolution of the lesion did not lead to complete repair in any case. The periosteum-free implant provided complete repair of the lesion and statistically significant restoration of the articular surface. CONCLUSIONS: In the rabbit, this study confirms the incomplete spontaneous repair of articular cartilage and the chondrogenic potential of tibial periosteum-free implants, with long-term maintenance of the macroscopic, histologic and histochemical characteristics of neo-cartilage. This raises the possibility of its use as an alternative method in the repair of circumscribed osteochondral lesions in young patients. Copyright 2000 OsteoArthritis Research Society International.
Authors: Xuan Guo; Hansoo Park; Simon Young; James D Kretlow; Jeroen J van den Beucken; L Scott Baggett; Yasuhiko Tabata; F Kurtis Kasper; Antonios G Mikos; John A Jansen Journal: Acta Biomater Date: 2009-08-04 Impact factor: 8.947
Authors: William J McCarty; Anna Luan; Priya Sundaramurthy; Caryn Urbanczyk; Atal Patel; Jacob Hahr; Mohammad Sotoudeh; Anthony Ratcliffe; Robert L Sah Journal: Ann Biomed Eng Date: 2010-11-24 Impact factor: 3.934
Authors: N Tanideh; S Dehghani Nazhvani; F Mojtahed Jaberi; D Mehrabani; S Rezazadeh; S Pakbaz; A Tamadon; B Nikahval Journal: Iran Red Crescent Med J Date: 2011-09-15 Impact factor: 0.611