Gene frequencies of the HPA-3 and HPA-5 platelet antigen alleles among the Amerindians.

Platelet antigens are of importance in several clinical situations and in population genetics. Data are scarce on allele frequencies in ethnic groups other than whites, Asians and African Americans. The frequencies of the alleles of the systems HPA-3 and HPA-5 were determined using the allele-specific restriction enzyme for five South American Amerindian populations and compared with those obtained for Afro-Americans, Japanese and whites from Brazil. The frequency of the HPA-3a allele among the Amerindians as a group did not differ from the values obtained for the other populations. However, differences were observed among the Amerindians, varying from 0.27 to 0.75, the highest frequency thus far observed for a population of Asian origin. Only the HPA-5a allele was found among 130 Amerindian chromosomes. The determination of gene frequencies of the HPA systems in different populations allows inference of gene flows and genetic constitution of populations and the estimation of the risk of platelet-specific alloimmunization.