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Literature DB >> 10966154

Anti-cancer activity studies of indolalthiohydantoin (PIT) on certain cancer cell lines.

Abstract

5-(2-Phenyl-3'-indolal)-2-thiohydantoin (PIT) has been evaluated as an anti-cancer compound on several cancer lines organised in to subpanels representing leukemia, melanoma, and cancer of lung, colon, kidney, ovary, breast, prostate and central nervous system by the National Cancer Institute (NCI) anti-cancer drug screen programme. The compound showed inhibitory activity on several cancer cell lines. No information is available on anti-cancer potency of this compound with normal cell lines.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2000 PMID： 10966154 DOI： 10.1016/s0014-827x(00)00028-8

Source DB: PubMed Journal: Farmaco ISSN： 0014-827X

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Cited

7 in total

1. Synthesis and antiproliferative and apoptosis-inducing activity of novel 3-substituted-3-hydroxy-2-oxindole compounds.

Authors: Mona Nazemi Moghaddam; Razieh Jalal; Zohreh Zeraatkar
Journal: In Vitro Cell Dev Biol Anim Date: 2017-11-09 Impact factor: 2.416

Review 2. The Molecular Diversity of 1H-Indole-3-Carbaldehyde Derivatives and Their Role in Multicomponent Reactions.

Authors: Ghodsi Mohammadi Ziarani; Samira Hasani; Fatemeh Mohajer; Rajender S Varma; Fatemeh Rafiee
Journal: Top Curr Chem (Cham) Date: 2022-04-25

3. Cu(II) complex with auxin (3-indoleacetic acid) and an aromatic planar ligand: synthesis, crystal structure, biomolecular interactions and radical scavenging activity.

Authors: Duygu İnci; Rahmiye Aydın; Yunus Zorlu
Journal: Eur Biophys J Date: 2021-04-30 Impact factor: 1.733

Anti-cancer activity studies of indolalthiohydantoin (PIT) on certain cancer cell lines.

1. Synthesis and antiproliferative and apoptosis-inducing activity of novel 3-substituted-3-hydroxy-2-oxindole compounds.

Review 2. The Molecular Diversity of 1H-Indole-3-Carbaldehyde Derivatives and Their Role in Multicomponent Reactions.

3. Cu(II) complex with auxin (3-indoleacetic acid) and an aromatic planar ligand: synthesis, crystal structure, biomolecular interactions and radical scavenging activity.

4. Synthesis and cytotoxic evaluation of novel 3-substituted derivatives of 2-indolinone.

5. Novel indole-based analogs of melatonin: synthesis and in vitro antioxidant activity studies.

6. An Efficient Synthesis of Acenaphtho[1,2-b]indole Derivatives via Domino Reaction.

7. Thermochemical Study of 1-Methylhydantoin.