| Literature DB >> 10965088 |
T Soeki1, Y Tamura, H Shinohara, H Tanaka, K Bando, N Fukuda.
Abstract
The time course of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) release in patients with acute myocardial infarction (AMI) is unknown. Blood samples were obtained at the time of admission and 3, 7, 14 and 21 days later in 32 patients with AMI and 30 control patients. Serum VEGF and HGF, as well as C-reactive protein (CRP) and amyloid A protein (SAA), were determined. Both serum VEGF and HGF levels on admission in patients with AMI were higher than control values and peaked on day 7. VEGF levels in patients with preinfarction angina were higher than in patients with no preinfarction angina, whereas the HGF level did not differ. Both CRP and SAA levels peaked on day 3, and the CRP level on day 3 correlate with both VEGF and HGF levels on day 7. We hypothesized that the serum VEGF level is associated with preinfarction ischemia and the increase in VEGF and HGF on day 7 of AMI may represent a response to acute inflammation. Copyright 2000 S. Karger AG, BaselEntities:
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Year: 2000 PMID： 10965088 DOI： 10.1159/000007022
Source DB: PubMed Journal: Cardiology ISSN： 0008-6312 Impact factor: 1.869