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Literature DB >> 10965020

Allelic loss of the region of chromosome 1p35-pter is associated with progression of human gastric carcinoma.

J Igarashi¹, Y Nimura, M Fujimori, M Mihara, W Adachi, H Kageyama, A Nakagawara.

Abstract

In order to identify the region on distal chromosome 1p that is thought to include one or more tumor suppressor genes for gastric carcinoma, 39 gastric carcinomas were examined for allelic loss using 11 polymorphic microsatellite markers and 1 marker of single strand conformation polymorphism. Loss of heterozygosity (LOH) was found in 18 (46%) of 39 informative patients. The regions with high frequency of loss of heterozygosity were the loci at D1S548 (6 / 17; 35.3%) and D1S2843 (7 / 20; 35%), and we found three commonly deleted regions on chromosome 1p35-pter. The frequency of allelic loss in the region of chromosome 1p35-pter was significantly associated with advanced-stage gastric carcinoma, but not with early-stage tumor or with the histology. These results suggest that allelic loss at chromosome 1p35-pter may play a role in the progression of gastric carcinoma.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2000 PMID： 10965020 PMCID： PMC5926431 DOI： 10.1111/j.1349-7006.2000.tb01016.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

27 in total

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Journal: Int J Cancer Date: 1998-11-09 Impact factor: 7.396

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Journal: Cancer Res Date: 1992-02-15 Impact factor: 12.701

5. Allelic loss at 1p is associated with tumor progression of meningiomas.

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Journal: Genes Chromosomes Cancer Date: 1994-04 Impact factor: 5.006

6. Human colorectal cancer: high frequency of deletions at chromosome 1p35.

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Journal: Cancer Res Date: 1990-11-15 Impact factor: 12.701

7. Expression of ERBB2 in human gastric carcinomas: relationship between p185ERBB2 expression and the gene amplification.

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Journal: Cancer Res Date: 1990-12-15 Impact factor: 12.701

8. A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3.

Authors: P S White; J M Maris; C Beltinger; E Sulman; H N Marshall; M Fujimori; B A Kaufman; J A Biegel; C Allen; C Hilliard; M B Valentine; A T Look; H Enomoto; S Sakiyama; G M Brodeur
Journal: Proc Natl Acad Sci U S A Date: 1995-06-06 Impact factor: 11.205

Allelic loss of the region of chromosome 1p35-pter is associated with progression of human gastric carcinoma.

Review 1. Genetic alterations in human gastric cancer.

2. p73, a gene related to p53, is not mutated in esophageal carcinomas.

3. Loss of heterozygosity for chromosome 11 in adenocarcinoma of the stomach.

4. Consistent association of 1p loss of heterozygosity with pheochromocytomas from patients with multiple endocrine neoplasia type 2 syndromes.

5. Allelic loss at 1p is associated with tumor progression of meningiomas.

6. Human colorectal cancer: high frequency of deletions at chromosome 1p35.

7. Expression of ERBB2 in human gastric carcinomas: relationship between p185ERBB2 expression and the gene amplification.

8. A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3.

9. Clonal allele loss in gastrointestinal cancers.

10. Allelotype of squamous cell carcinoma of the head and neck: fractional allele loss correlates with survival.

1. GADD45A expression is correlated with patient prognosis in esophageal cancer.

2. cDNA suppression subtraction library for screening down-regulated genes in gastric carcinoma.

3. Cloning and expression analysis of the gastric carcinoma-related gene, ELCOX3.