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Literature DB >> 10964434

A high-throughput screen to identify inhibitors of aromatase (CYP19).

D M Stresser¹, S D Turner, J McNamara, P Stocker, V P Miller, C L Crespi, C J Patten.

Abstract

Entities: Gene

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Year: 2000 PMID： 10964434 DOI： 10.1006/abio.2000.4729

Source DB: PubMed Journal: Anal Biochem ISSN： 0003-2697 Impact factor: 3.365

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20 in total

1. Development of a new class of aromatase inhibitors: design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives.

Authors: Kevin Bonfield; Erica Amato; Tony Bankemper; Hannah Agard; Jeffrey Steller; James M Keeler; David Roy; Adam McCallum; Stefan Paula; Lili Ma
Journal: Bioorg Med Chem Date: 2012-02-27 Impact factor: 3.641

2. Metabolism of bupropion by baboon hepatic and placental microsomes.

Authors: Xiaoming Wang; Doaa R Abdelrahman; Valentina M Fokina; Gary D V Hankins; Mahmoud S Ahmed; Tatiana N Nanovskaya
Journal: Biochem Pharmacol Date: 2011-05-05 Impact factor: 5.858

3. Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues.

Authors: Yuan Wei; Xin Zhou; Cheng Fang; Lei Li; Kerri Kluetzman; Weizhu Yang; Qing-Yu Zhang; Xinxin Ding
Journal: J Pharmacol Exp Ther Date: 2010-04-07 Impact factor: 4.030

A high-throughput screen to identify inhibitors of aromatase (CYP19).

1. Development of a new class of aromatase inhibitors: design, synthesis and inhibitory activity of 3-phenylchroman-4-one (isoflavanone) derivatives.

2. Metabolism of bupropion by baboon hepatic and placental microsomes.

3. Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues.

4. Discovery of novel aromatase inhibitors using a homogeneous time-resolved fluorescence assay.

5. Sequence-function correlation of aromatase and its interaction with reductase.

6. High-affinity binding of [3H]cimetidine to a heme-containing protein in rat brain.

7. Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors.

8. Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide.

9. Aromatase inhibition by bioavailable methylated flavones.

Review 10. Molecular characterization of aromatase.