Literature DB >> 10964378

Preparation and characterization of cholic acid-derived antimicrobial agents with controlled stabilities.

Q Guan1, C Li, E J Schmidt, J S Boswell, J P Walsh, G W Allman, P B Savage.   

Abstract

[reaction: see text] Novel cholic acid-derived antimicrobial agents that decompose under mildly basic conditions have been prepared. These compounds range in biological properties from potent antibacterial activity to effective permeabilization of the outer membranes of Gram-negative bacteria.

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Year:  2000        PMID： 10964378     DOI： 10.1021/ol0062704

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  11 in total

1.  Antimicrobial activities of ceragenins against clinical isolates of resistant Staphylococcus aureus.

Authors:  Judy N Chin; Michael J Rybak; Chrissy M Cheung; Paul B Savage
Journal:  Antimicrob Agents Chemother       Date:  2007-01-08       Impact factor: 5.191

2.  Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate.

Authors:  Robert Bucki; Katarzyna Leszczynska; Fitzroy J Byfield; David E Fein; Esther Won; Katrina Cruz; Andrzej Namiot; Alina Kulakowska; Zbigniew Namiot; Paul B Savage; Scott L Diamond; Paul A Janmey
Journal:  Antimicrob Agents Chemother       Date:  2010-03-22       Impact factor: 5.191

3.  N-methyl Benzimidazole Tethered Cholic Acid Amphiphiles Can Eradicate S. aureus-Mediated Biofilms and Wound Infections.

Authors:  Himanshu Kakkar; Nalini Chaudhary; Devashish Mehta; Varsha Saini; Shallu Maheshwari; Jitender Singh; Preeti Walia; Avinash Bajaj
Journal:  Molecules       Date:  2022-05-30       Impact factor: 4.927

4.  Minimum requirements of hydrophobic and hydrophilic features in cationic peptide antibiotics (CPAs): pharmacophore generation and validation with cationic steroid antibiotics (CSAs).

Authors:  Sandeep Sundriyal; Rohit K Sharma; Rahul Jain; Prasad V Bharatam
Journal:  J Mol Model       Date:  2008-02-13       Impact factor: 1.810

5.  In Vitro Activities of the Cationic Steroid Antibiotics CSA-13, CSA-131, CSA-138, CSA-142, and CSA-192 Against Carbapenem-resistant Pseudomonas aeruginosa.

Authors:  Çağla Bozkurt Güzel; Nevin Meltem Avci; Paul Savage
Journal:  Turk J Pharm Sci       Date:  2020-02-19

6.  Antimicrobial ceragenins inhibit biofilms and affect mammalian cell viability and migration in vitro.

Authors:  Melissa A Olekson; Tao You; Paul B Savage; Kai P Leung
Journal:  FEBS Open Bio       Date:  2017-05-22       Impact factor: 2.693

7.  Comparative In Vitro Activities of First and Second-Generation Ceragenins Alone and in Combination with Antibiotics Against Multidrug-Resistant Klebsiella pneumoniae Strains.

Authors:  Berna Ozbek-Celik; Damla Damar-Celik; Emel Mataraci-Kara; Cagla Bozkurt-Guzel; Paul B Savage
Journal:  Antibiotics (Basel)       Date:  2019-08-27

Review 8.  Physiology and Physical Chemistry of Bile Acids.

Authors:  Maria Chiara di Gregorio; Jacopo Cautela; Luciano Galantini
Journal:  Int J Mol Sci       Date:  2021-02-10       Impact factor: 5.923

9.  Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms.

Authors:  Gabriel Mitchell; Melanie R Silvis; Kelsey C Talkington; Jonathan M Budzik; Claire E Dodd; Justin M Paluba; Erika A Oki; Kristine L Trotta; Daniel J Licht; David Jimenez-Morales; Seemay Chou; Paul B Savage; Carol A Gross; Michael A Marletta; Jeffery S Cox
Journal:  mBio       Date:  2022-01-25       Impact factor: 7.867

10.  Potential synergy activity of the novel ceragenin, CSA-13, against carbapenem-resistant Acinetobacter baumannii strains isolated from bacteremia patients.

Authors:  Cagla Bozkurt-Guzel; Paul B Savage; Alper Akcali; Berna Ozbek-Celik
Journal:  Biomed Res Int       Date:  2014-03-24       Impact factor: 3.411
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