Literature DB >> 1096275

A double-blind cross-over trail of Prenazone and aspirin in the management of rheumatoid arthritis.

R Billings, H C Burry, R Grahame, D J Berry, B Donovan.   

Abstract

A double-blind cross-over trial of Prenazone 600 mg and Aspirin 4 g daily was carried out on 20 patients suffering with rheumatoid arthritis. The analgesic and anti-inflammmatory activity was indistinguishable from that of aspirin under the conditions of the trail. Twelve patients expressed a general preference for Prenazone and six for aspirin. Prenazone appeared to be well tolerated and free from serious side-effects. These results suggest that it will be a useful drug in the management of rheumatoid arthritis.

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Year:  1975        PMID： 1096275     DOI： 10.1093/rheumatology/14.2.61

Source DB:  PubMed          Journal:  Rheumatol Rehabil        ISSN： 0300-3396


  3 in total

1.  Rectal administration of feprazone in healthy volunteers.

Authors:  P Ferrari; C Montanari; P Sala; A Vidi
Journal:  Br J Clin Pharmacol       Date:  1976-04       Impact factor: 4.335

2.  Incidence of gastric side effects in controlled trials with unbranded aspirin and with various long-acting aspirin preparations.

Authors:  J M Gumpel
Journal:  Ann Rheum Dis       Date:  1978-08       Impact factor: 19.103

3.  An analysis of the gastro-intestinal side-effects of non-steroidal anti-inflammatory drugs, with particular reference to comparative studies in man and laboratory species.

Authors:  K D Rainsford
Journal:  Rheumatol Int       Date:  1982       Impact factor: 2.631
  3 in total

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