Literature DB >> 10962281

Why do we lack an effective vaccine against herpes simplex virus infections?

S P Deshpande1, U Kumaraguru, B T Rouse.   

Abstract

This review discusses the possible causes for the lack of an effective antiherpes vaccine. Future prospects of vaccines based on the current knowledge of immune responses to herpes viruses are discussed. It is argued that vaccines capable of expanding CD8 T-cell memory responses should be the focus of future anti-herpes simplex virus research.

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Year:  2000        PMID: 10962281     DOI: 10.1016/s1286-4579(00)00339-7

Source DB:  PubMed          Journal:  Microbes Infect        ISSN: 1286-4579            Impact factor:   2.700


  8 in total

1.  Therapeutic immunization with a virion host shutoff-defective, replication-incompetent herpes simplex virus type 1 strain limits recurrent herpetic ocular infection.

Authors:  Tammie L Keadle; Lynda A Morrison; Jessica L Morris; Jay S Pepose; Patrick M Stuart
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

2.  Effector CD4+ T-cell involvement in clearance of infectious herpes simplex virus type 1 from sensory ganglia and spinal cords.

Authors:  Alison J Johnson; Chin-Fun Chu; Gregg N Milligan
Journal:  J Virol       Date:  2008-07-30       Impact factor: 5.103

Review 3.  Herpes simplex virus type 2 vaccines: new ground for optimism?

Authors:  L Aurelian
Journal:  Clin Diagn Lab Immunol       Date:  2004-05

4.  Permissive and restricted virus infection of murine embryonic stem cells.

Authors:  Rachael Wash; Sabrina Calabressi; Stephanie Franz; Samantha J Griffiths; David Goulding; E-Pien Tan; Helen Wise; Paul Digard; Jürgen Haas; Stacey Efstathiou; Paul Kellam
Journal:  J Gen Virol       Date:  2012-07-18       Impact factor: 3.891

Review 5.  Developments in herpes simplex virus vaccines: old problems and new challenges.

Authors:  J Rajcáni; V Durmanová
Journal:  Folia Microbiol (Praha)       Date:  2006       Impact factor: 2.629

6.  Characterization of the IFN-gamma T-cell responses to immediate early antigens in humans with genital herpes.

Authors:  Ralph P Braun; Lendon G Payne; Lichun Dong
Journal:  Virol J       Date:  2006-07-05       Impact factor: 4.099

7.  Hinge Region in DNA Packaging Terminase pUL15 of Herpes Simplex Virus: A Potential Allosteric Target for Antiviral Drugs.

Authors:  Lana F Thaljeh; J Ainsley Rothschild; Misagh Naderi; Lyndon M Coghill; Jeremy M Brown; Michal Brylinski
Journal:  Biomolecules       Date:  2019-10-12

Review 8.  Mucosal herpes immunity and immunopathology to ocular and genital herpes simplex virus infections.

Authors:  Aziz Alami Chentoufi; Lbachir Benmohamed
Journal:  Clin Dev Immunol       Date:  2012-12-24
  8 in total

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