Literature DB >> 10962230

Enhanced permeation of triamcinolone acetonide through the buccal mucosa.

S C Shin1, J Y Kim.   

Abstract

To develop new formulations that have suitable bioadhesive force and provide sustained release in buccal area for an extended period of time, bioadhesive gels containing triamcinolone acetonide were prepared using two polymers, carbopol 934 and poloxamer 407 which were selected for their bioadhesiveness and gelling property, respectively. The drug release profiles from the gels were studied as a function of drug concentration and temperature. Different enhancers such as bile salts, glycols and non-ionic surfactants were used for the enhancement of its permeation through buccal mucosa. Among the enhancers used, sodium deoxycholate showed the best enhancing effects.

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Year:  2000        PMID： 10962230     DOI： 10.1016/s0939-6411(00)00101-6

Source DB:  PubMed          Journal:  Eur J Pharm Biopharm        ISSN： 0939-6411            Impact factor:   5.571


  11 in total

Review 1.  A review of poloxamer 407 pharmaceutical and pharmacological characteristics.

Authors:  Gilles Dumortier; Jean Louis Grossiord; Florence Agnely; Jean Claude Chaumeil
Journal:  Pharm Res       Date:  2006-11-11       Impact factor: 4.200

2.  Development and in vitro-in vivo evaluation of fenretinide-loaded oral mucoadhesive patches for site-specific chemoprevention of oral cancer.

Authors:  Kashappa-Goud H Desai; Susan R Mallery; Andrew S Holpuch; Steven P Schwendeman
Journal:  Pharm Res       Date:  2011-06-15       Impact factor: 4.200

3.  Effect of freezing and type of mucosa on ex vivo drug permeability parameters.

Authors:  Thiago Caon; Cláudia Maria Oliveira Simões
Journal:  AAPS PharmSciTech       Date:  2011-05-04       Impact factor: 3.246

Review 4.  Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine.

Authors:  Yosra S R Elnaggar
Journal:  Int J Nanomedicine       Date:  2015-06-12

5.  Surfactants modify the release from tablets made of hydrophobically modified poly (acrylic acid).

Authors:  Patrik Knöös; Sebla Onder; Lina Pedersen; Lennart Piculell; Stefan Ulvenlund; Marie Wahlgren
Journal:  Results Pharma Sci       Date:  2013-09-13

Review 6.  A clinical perspective on mucoadhesive buccal drug delivery systems.

Authors:  Ritu M Gilhotra; Mohd Ikram; Sunny Srivastava; Neeraj Gilhotra
Journal:  J Biomed Res       Date:  2013-06-06

7.  Transbuccal delivery of betahistine dihydrochloride from mucoadhesive tablets with a unidirectional drug flow: in vitro, ex vivo and in vivo evaluation.

Authors:  Mohamed A El-Nabarawi; Adel A Ali; Heba M Aboud; Amira H Hassan; Amany H Godah
Journal:  Drug Des Devel Ther       Date:  2016-12-14       Impact factor: 4.162

8.  Enhanced Controlled Transdermal Delivery of Ambroxol from the EVA Matrix.

Authors:  C W Cho; D B Kim; H W Cho; S C Shin
Journal:  Indian J Pharm Sci       Date:  2012-03       Impact factor: 0.975

9.  Insights into and relative effect of chitosan-H, chitosan-H-propolis, chitosan-H-propolis-nystatin and chitosan-H-nystatin on dentine bond strength.

Authors:  Victoria Tamara Perchyonok; Shengmiao Zhang; Sias R Grobler; Theunis G Oberholzer
Journal:  Eur J Dent       Date:  2013-10

10.  Enhanced Permeation of an Antiemetic Drug from Buccoadhesive Tablets by Using Bile Salts as Permeation Enhancers: Formulation Characterization, In Vitro, and Ex Vivo Studies.

Authors:  C P Jain; Garima Joshi; Udichi Kataria; Komal Patel
Journal:  Sci Pharm       Date:  2015-07-29
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