| Literature DB >> 10960769 |
L Tao1, S Yang, M Xie, P M Kramer, M A Pereira.
Abstract
Dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are mouse liver carcinogens. Methylation of the c-jun and c-myc genes, expression of both genes and DNA methyltransferase (DNA MTase) activity were determined in liver tumors initiated by N-methyl-N-nitrosourea and promoted by DCA and TCA in female B6C3F1 mice. Hypomethylated and over-expression of c-jun and c-myc genes were found in DCA- and TCA-promoted liver tumors. DNA MTase activity was increased in tumors while decreased in non-involved liver. Thus, DCA- and TCA-promoted carcinogenesis appears to include decreased methylation and increased expression of c-jun and c-myc genes in the presence of increased DNA MTase activity.Entities:
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Year: 2000 PMID： 10960769 DOI： 10.1016/s0304-3835(00)00518-8
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679