Literature DB >> 10960768

Correlation of telomere lengths in normal and cancers tissue in the large bowel.

K Nakamura1, E Furugori, Y Esaki, T Arai, M Sawabe, I Okayasu, M Fujiwara, M Kammori, K Mafune, M Kato, M Oshimura, K Sasajima, K Takubo.   

Abstract

The hypothesis that telomeres in colorectal cancer cells exhibit age-related shortening, as in normal cells of the colorectal epithelium, was tested with samples of non-cancerous mucosa and cancer tissue from 124 patients (aged 29-97 years). Shortening with aging could be demonstrated for both normal and cancer tissues; regression analysis showed rates for length reduction of 44 and 50 base pair/year, respectively. Straight, essentially parallel, lines were obtained for the two cases, normal tissue values being about 2 kilobase pairs (kbp) higher, with a significant correlation between data at the individual patient level.

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Year:  2000        PMID： 10960768     DOI： 10.1016/s0304-3835(00)00521-8

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  23 in total

1.  The relationship between telomere length and clinicopathologic characteristics in colorectal cancers among Tunisian patients.

Authors:  Raja Mzahma; Maher Kharrat; Fadhel Fetiriche; Mounir Ben Moussa; Zoubeir Ben Safta; Chadli Dziri; AbdelJelil Zaouche; Habiba Chaabouni-Bouhamed
Journal:  Tumour Biol       Date:  2015-06-06

Review 2.  Telomeres, telomerase and colorectal cancer.

Authors:  Roberta Bertorelle; Enrica Rampazzo; Salvatore Pucciarelli; Donato Nitti; Anita De Rossi
Journal:  World J Gastroenterol       Date:  2014-02-28       Impact factor: 5.742

3.  Correlation of telomere length to malignancy potential in non-melanoma skin cancers.

Authors:  Hanae Yamada-Hishida; Yoshimasa Nobeyama; Hidemi Nakagawa
Journal:  Oncol Lett       Date:  2017-10-26       Impact factor: 2.967

Review 4.  The chromosomal instability pathway in colon cancer.

Authors:  Maria S Pino; Daniel C Chung
Journal:  Gastroenterology       Date:  2010-06       Impact factor: 22.682

5.  Telomere shortening occurs early during gastrocarcinogenesis.

Authors:  Yunchuan Mu; Qing Zhang; Linhang Mei; Xiaosun Liu; Weili Yang; Jiren Yu
Journal:  Med Oncol       Date:  2011-02-27       Impact factor: 3.064

6.  Telomere function in colorectal cancer.

Authors:  Cristina Frías; Alberto Morán; Carmen de Juan; Paloma Ortega; Tamara Fernández-Marcelo; Andrés Sánchez-Pernaute; Antonio José Torres; Eduardo Díaz-Rubio; Manuel Benito; Pilar Iniesta
Journal:  World J Gastrointest Oncol       Date:  2009-10-15

7.  Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements.

Authors:  Boitelo T Letsolo; Jan Rowson; Duncan M Baird
Journal:  Nucleic Acids Res       Date:  2009-12-21       Impact factor: 16.971

8.  Telomere shortening of epithelial cells characterises the adenoma-carcinoma transition of human colorectal cancer.

Authors:  R R Plentz; S U Wiemann; P Flemming; P N Meier; S Kubicka; H Kreipe; M P Manns; K L Rudolph
Journal:  Gut       Date:  2003-09       Impact factor: 23.059

9.  Obesity and telomere status in the prognosis of patients with colorectal cancer submitted to curative intention surgical treatment.

Authors:  Sergio García-Martínez; Daniel González-Gamo; Tamara Fernández-Marcelo; Sofía Tesolato; Sofía De La Serna; Inmaculada Domínguez-Serrano; Oscar Cano-Valderrama; Ana Barabash; Carmen De Juan; Antonio Torres-García; Pilar Iniesta
Journal:  Mol Clin Oncol       Date:  2021-07-03

Review 10.  Telomeres and telomere dynamics: relevance to cancers of the GI tract.

Authors:  Nivedita Basu; Halcyon G Skinner; Kristin Litzelman; Russell Vanderboom; Esha Baichoo; Lisa A Boardman
Journal:  Expert Rev Gastroenterol Hepatol       Date:  2013-11       Impact factor: 3.869
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