G K Frank1, W H Kaye, M Altemus, C G Greeno. 1. Department of Psychiatry, University of Pittsburgh, School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA.
Abstract
BACKGROUND: When ill, people with eating disorders have disturbances of the neuropeptides vasopressin and oxytocin. METHODS: To avoid the confounding effects of the ill state, we studied women who were recovered (more than 1 year, normal weight, and regular menstrual cycles, no bingeing or purging) from bulimia nervosa (rBN) or binge eating/purging-type anorexia nervosa (rAN-BN), and matched healthy control women. RESULTS: Vasopressin was elevated in rAN-BN and showed a trend towards elevation in rBN. In rBN, elevated cerebrospinal fluid vasopressin may be related to having a lifetime history of major depression. In comparison, cerebrospinal fluid oxytocin was normal in recovered subjects, but elevated levels in some rBN might be related to birth control pill use. CONCLUSIONS: These data confirm and extend the possibility that elevated cerebrospinal fluid vasopressin may be related to the pathophysiology of eating disorders, and/or a lifetime history of major depression.
BACKGROUND: When ill, people with eating disorders have disturbances of the neuropeptides vasopressin and oxytocin. METHODS: To avoid the confounding effects of the ill state, we studied women who were recovered (more than 1 year, normal weight, and regular menstrual cycles, no bingeing or purging) from bulimia nervosa (rBN) or binge eating/purging-type anorexia nervosa (rAN-BN), and matched healthy control women. RESULTS:Vasopressin was elevated in rAN-BN and showed a trend towards elevation in rBN. In rBN, elevated cerebrospinal fluid vasopressin may be related to having a lifetime history of major depression. In comparison, cerebrospinal fluid oxytocin was normal in recovered subjects, but elevated levels in some rBN might be related to birth control pill use. CONCLUSIONS: These data confirm and extend the possibility that elevated cerebrospinal fluid vasopressin may be related to the pathophysiology of eating disorders, and/or a lifetime history of major depression.
Authors: Elizabeth A Lawson; Daniel A Donoho; Justine I Blum; Erinne M Meenaghan; Madhusmita Misra; David B Herzog; Patrick M Sluss; Karen K Miller; Anne Klibanski Journal: J Clin Psychiatry Date: 2011-08-09 Impact factor: 4.384
Authors: Anna Aulinas; Franziska Plessow; Reitumetse L Pulumo; Elisa Asanza; Christopher J Mancuso; Meghan Slattery; Christiane Tolley; Jennifer J Thomas; Kamryn T Eddy; Karen K Miller; Anne Klibanski; Madhusmita Misra; Elizabeth A Lawson Journal: J Clin Endocrinol Metab Date: 2019-10-01 Impact factor: 5.958