BACKGROUND: Neurobiologic abnormalities in the thalamus have been implicated in the pathophysiology of obsessive-compulsive disorder. We recently reported increased thalamic volume in treatment-naive pediatric obsessive-compulsive disorder patients versus case-matched healthy comparison subjects that decreased to levels comparable to control subjects after effective paroxetine therapy. To our knowledge, no prior study has measured neuroanatomic changes in the thalamus of obsessive-compulsive disorder patients near illness onset before and after cognitive behavioral therapy. METHODS: Volumetric magnetic resonance imaging studies were conducted in 11 psychotropic drug-naive 8-17-year-old children with obsessive-compulsive disorder before and after 12 weeks of effective cognitive behavioral therapy monotherapy (> or =30% reduction in obsessive-compulsive disorder symptom severity). RESULTS: No significant change in thalamic volume was observed in obsessive-compulsive disorder patients before and after cognitive behavioral therapy. CONCLUSIONS: Our findings suggest that reduction in thalamic volume after paroxetine therapy may be specific to paroxetine treatment and not the result of a general treatment response or spontaneous improvement. These results are preliminary in view of the small sample studied.
BACKGROUND: Neurobiologic abnormalities in the thalamus have been implicated in the pathophysiology of obsessive-compulsive disorder. We recently reported increased thalamic volume in treatment-naive pediatric obsessive-compulsive disorderpatients versus case-matched healthy comparison subjects that decreased to levels comparable to control subjects after effective paroxetine therapy. To our knowledge, no prior study has measured neuroanatomic changes in the thalamus of obsessive-compulsive disorderpatients near illness onset before and after cognitive behavioral therapy. METHODS: Volumetric magnetic resonance imaging studies were conducted in 11 psychotropic drug-naive 8-17-year-old children with obsessive-compulsive disorder before and after 12 weeks of effective cognitive behavioral therapy monotherapy (> or =30% reduction in obsessive-compulsive disorder symptom severity). RESULTS: No significant change in thalamic volume was observed in obsessive-compulsive disorderpatients before and after cognitive behavioral therapy. CONCLUSIONS: Our findings suggest that reduction in thalamic volume after paroxetine therapy may be specific to paroxetine treatment and not the result of a general treatment response or spontaneous improvement. These results are preliminary in view of the small sample studied.
Authors: Paul Daniel Arnold; Frank P Macmaster; Gregory L Hanna; Margaret A Richter; Tricia Sicard; Eliza Burroughs; Yousha Mirza; Phillip C Easter; Michelle Rose; James L Kennedy; David R Rosenberg Journal: Brain Imaging Behav Date: 2009-03-01 Impact factor: 3.978
Authors: Premika S W Boedhoe; Lianne Schmaal; Yoshinari Abe; Stephanie H Ameis; Paul D Arnold; Marcelo C Batistuzzo; Francesco Benedetti; Jan C Beucke; Irene Bollettini; Anushree Bose; Silvia Brem; Anna Calvo; Yuqi Cheng; Kang Ik K Cho; Sara Dallaspezia; Damiaan Denys; Kate D Fitzgerald; Jean-Paul Fouche; Mònica Giménez; Patricia Gruner; Gregory L Hanna; Derrek P Hibar; Marcelo Q Hoexter; Hao Hu; Chaim Huyser; Keisuke Ikari; Neda Jahanshad; Norbert Kathmann; Christian Kaufmann; Kathrin Koch; Jun Soo Kwon; Luisa Lazaro; Yanni Liu; Christine Lochner; Rachel Marsh; Ignacio Martínez-Zalacaín; David Mataix-Cols; José M Menchón; Luciano Minuzzi; Takashi Nakamae; Tomohiro Nakao; Janardhanan C Narayanaswamy; Fabrizio Piras; Federica Piras; Christopher Pittenger; Y C Janardhan Reddy; Joao R Sato; H Blair Simpson; Noam Soreni; Carles Soriano-Mas; Gianfranco Spalletta; Michael C Stevens; Philip R Szeszko; David F Tolin; Ganesan Venkatasubramanian; Susanne Walitza; Zhen Wang; Guido A van Wingen; Jian Xu; Xiufeng Xu; Je-Yeon Yun; Qing Zhao; Paul M Thompson; Dan J Stein; Odile A van den Heuvel Journal: Am J Psychiatry Date: 2016-09-09 Impact factor: 18.112