Literature DB >> 10959764

Therapeutic approaches to Alzheimer's disease.

E D Thorsett1, L H Latimer.   

Abstract

Several recent advances have provided new insights and possibilities in defining therapeutic targets for Alzheimer's disease. Of particular importance is the identification of the beta-secretase enzyme and the demonstration that immunization of a transgenic mouse model of Alzheimer's disease with Abeta(1-42) peptide can prevent or alleviate neuropathological features of the disease.

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Year:  2000        PMID： 10959764     DOI： 10.1016/s1367-5931(00)00102-2

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  3 in total

1.  Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation.

Authors:  Cheng-Shi Jiang; Yong-Xi Ge; Zhi-Qiang Cheng; Jia-Li Song; Yin-Yin Wang; Kongkai Zhu; Hua Zhang
Journal:  J Comput Aided Mol Des       Date:  2019-04-15       Impact factor: 3.686

Review 2.  Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer's disease.

Authors:  Wen-Yu Wu; Yu-Chen Dai; Nian-Guang Li; Ze-Xi Dong; Ting Gu; Zhi-Hao Shi; Xin Xue; Yu-Ping Tang; Jin-Ao Duan
Journal:  J Enzyme Inhib Med Chem       Date:  2017-12       Impact factor: 5.051

3.  A novel rhamnoside derivative PL402 up-regulates matrix metalloproteinase 3/9 to promote Aβ degradation and alleviates Alzheimer's-like pathology.

Authors:  Tingting Hu; Yue Zhou; Jing Lu; Peng Xia; Yue Chen; Xin Cao; Gang Pei
Journal:  Aging (Albany NY)       Date:  2020-01-05       Impact factor: 5.682
  3 in total

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