| Literature DB >> 10959032 |
T Lynch1, R A Cherny, A I Bush.
Abstract
Alzheimer's disease is characterized by signs of a major oxidative stress in the neocortex and the concomitant deposition of Amyloid beta (Abeta). Abeta is a metalloprotein that binds copper, and is electrochemically active. Abeta converts molecular oxygen into hydrogen peroxide by reducing copper or iron, and this may lead to Fenton chemistry. Hydrogen peroxide is a freely permeable prooxidant that may be responsible for many of the oxidative adducts that form in the Alzheimer-affected brain. The electrochemical activity of various Abeta species correlates with the peptides' neurotoxicity in cell culture, and participation in the neuropathology of Alzheimer's disease. These reactions present a novel target for Alzheimer therapeutics.Entities:
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Year: 2000 PMID： 10959032 DOI： 10.1016/s0531-5565(00)00112-1
Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032