Literature DB >> 10959003

PACAP38 and PACAP27 administered intracerebroventricularly have an opposite effect on LH secretion.

O Kántora1, J Molnár, A Arimura, K Köves.   

Abstract

The effect of PACAP38 on the LH surge and ovulation was compared with that of PACAP27 and VIP in the same model. The peptides were administered intracerebroventricularly before the critical period of the proestrous stage. PACAP38 was able to inhibit ovulation and to prevent the preovulatory LH surge; however, PACAP27 did not inhibit the ovulation and VIP inhibited the ovulation in 2/11 animals. In those animals of the last two groups in which ovulation occurred, the preovulatory LH surge was higher than in control rats. It is speculated that the opposite effect of PACAP38 and PACAP27 on the preovulatory LH surge and ovulation is possibly mediated through different receptors.

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Year:  2000        PMID： 10959003     DOI： 10.1016/s0196-9781(00)00214-x

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  8 in total

Review 1.  PACAP: A regulator of mammalian reproductive function.

Authors:  Stephen J Winters; Joseph P Moore
Journal:  Mol Cell Endocrinol       Date:  2020-06-17       Impact factor: 4.102

2.  Pituitary adenylate cyclase-activating polypeptide does not colocalize with vasoactive intestinal polypeptide in the hypothalamic magnocellular nuclei and posterior pituitary of cats and rats.

Authors:  Viktoria Vereczki; Katalin Köves; Zsuzsanna E Tóth; Akemichi Baba; Hitoshi Hashimoto; Kristóf Fógel; Akira Arimura; Mária Kausz
Journal:  Endocrine       Date:  2003-12       Impact factor: 3.633

3.  PACAP27 is protective against tat-induced neurotoxicity.

Authors:  Summer J Rozzi; Giulia Borelli; Kerry Ryan; Joseph P Steiner; Dora Reglodi; Italo Mocchetti; Valeriya Avdoshina
Journal:  J Mol Neurosci       Date:  2014-04-04       Impact factor: 3.444

Review 4.  Advent and recent advances in research on the role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the regulation of gonadotropic hormone secretion of female rats.

Authors:  Katalin Köves; Orsolya Kántor; András Lakatos; Enikő Szabó; Eszter Kirilly; Andrea Heinzlmann; Flóra Szabó
Journal:  J Mol Neurosci       Date:  2014-04-03       Impact factor: 3.444

5.  Passage through the Ocular Barriers and Beneficial Effects in Retinal Ischemia of Topical Application of PACAP1-38 in Rodents.

Authors:  Dora Werling; William A Banks; Therese S Salameh; Timea Kvarik; Laszlo Akos Kovacs; Alexandra Vaczy; Edina Szabo; Flora Mayer; Rita Varga; Andrea Tamas; Gabor Toth; Zsolt Biro; Tamas Atlasz; Dora Reglodi
Journal:  Int J Mol Sci       Date:  2017-03-21       Impact factor: 5.923

Review 6.  Female reproductive functions of the neuropeptide PACAP.

Authors:  Miklos Koppan; Zsuzsanna Nagy; Inez Bosnyak; Dora Reglodi
Journal:  Front Endocrinol (Lausanne)       Date:  2022-09-20       Impact factor: 6.055

7.  Nimodipine, a calcium channel blocker, delays the spontaneous LH surge in women with regular menstrual cycles: a prospective pilot study.

Authors:  Dan Nayot; Shany Klachook; Robert F Casper
Journal:  Reprod Biol Endocrinol       Date:  2013-02-07       Impact factor: 5.211

Review 8.  Current State of Understanding of the Role of PACAP in the Hypothalamo-Hypophyseal Gonadotropin Functions of Mammals.

Authors:  Katalin Köves; Enikő Szabó; Orsolya Kántor; Andrea Heinzlmann; Flóra Szabó; Ágnes Csáki
Journal:  Front Endocrinol (Lausanne)       Date:  2020-03-06       Impact factor: 5.555
  8 in total

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