Literature DB >> 10958926

On the nature of aging.

I Semsei1.   

Abstract

Most of the aging theories are monistic in nature, they omit numerous key factors of senescence during the process of model creation. There are two main categories of these theories: program theories and error (mutation) ones. Program theories imply the existence of internal or external programs that determine the aging process ab ovo. The error theories involve explicit or implicit the idea that aging would not happen without the destructive factors that cause errors, mutations, regulation disorders, and in turn these processes finally lead to disfunctions and senescence. The aim of this paper is to indicate that aging may be multifactorial and the process of senescence may be determined by the information level of the organization. This level itself changes during senescence (including the information level of the genom that also alters by time because of, e.g. its 'fluid' character). According to this approach the aging process is determined by the sum effects of internal (e.g. genom) and external (material, energy, information) factors, although there are some elements that bear more importance than others. Subsequently, the maximal life-span is probably determined by the principle of the weakest element of the chain. Because of the high complexity of the human body where different information systems superpose each other, the cooperation of the elements (counter-effects, regulation) have the same determining importance as the information level of the unit parts (cells) have. The further aim of this paper is to show that the roots of certain diseases (e.g. cancer) could firmly be linked to the aging process itself. This interpretation offers two ways of influencing the process of senescence. It could be influenced by maintaining the information level of the organism via optimization or by changing (elevating) this level. All the factors that help to prevent the decrease of the information level of the organism could act against aging and certain diseases, and vice versa: the factors which deteriorate the state of the information system could contribute to the acceleration of the aging process.

Entities:  

Mesh:

Year:  2000        PMID: 10958926     DOI: 10.1016/s0047-6374(00)00147-0

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN: 0047-6374            Impact factor:   5.432


  11 in total

Review 1.  A hypothesis to explain ganglion cell death caused by vascular insults at the optic nerve head: possible implication for the treatment of glaucoma.

Authors:  N N Osborne; J Melena; G Chidlow; J P Wood
Journal:  Br J Ophthalmol       Date:  2001-10       Impact factor: 4.638

2.  Chromosomal changes in ageing.

Authors:  Predrag Erceg; Dragoslav P Milosevic; Nebojsa Despotovic; Mladen Davidovic
Journal:  J Genet       Date:  2007-12       Impact factor: 1.166

Review 3.  A synopsis on aging-Theories, mechanisms and future prospects.

Authors:  João Pinto da Costa; Rui Vitorino; Gustavo M Silva; Christine Vogel; Armando C Duarte; Teresa Rocha-Santos
Journal:  Ageing Res Rev       Date:  2016-06-25       Impact factor: 10.895

4.  Human brain imaging of nicotinic acetylcholine α4β2* receptors using [18 F]Nifene: Selectivity, functional activity, toxicity, aging effects, gender effects, and extrathalamic pathways.

Authors:  Jogeshwar Mukherjee; Patrick J Lao; Tobey J Betthauser; Gurleen K Samra; Min-Liang Pan; Ishani H Patel; Christopher Liang; Raju Metherate; Bradley T Christian
Journal:  J Comp Neurol       Date:  2017-09-19       Impact factor: 3.215

5.  The protective effect of trimetazidine on myocardial ischemia/reperfusion injury through activating AMPK and ERK signaling pathway.

Authors:  Zhenling Liu; Ji-Mei Chen; Huanlei Huang; Michelle Kuznicki; Shaoyi Zheng; Wanqing Sun; Nanhu Quan; Lin Wang; Hui Yang; Hui-Ming Guo; Ji Li; Jian Zhuang; Ping Zhu
Journal:  Metabolism       Date:  2015-10-19       Impact factor: 8.694

6.  Melatonin is able to delay endoplasmic reticulum stress-induced apoptosis in leukocytes from elderly humans.

Authors:  Javier Espino; Ignacio Bejarano; Sergio D Paredes; Carmen Barriga; Russel J Reiter; José A Pariente; Ana B Rodríguez
Journal:  Age (Dordr)       Date:  2010-11-18

7.  Effects of calorie restriction on chromosomal stability in rhesus monkeys (Macaca mulatta).

Authors:  Charleen M Moore; Betty G Dunn; C Alex McMahan; Mark A Lane; George S Roth; Donald K Ingram; Julie A Mattison
Journal:  Age (Dordr)       Date:  2006-11-21

Review 8.  Redox control of the cell cycle in health and disease.

Authors:  Ehab H Sarsour; Maneesh G Kumar; Leena Chaudhuri; Amanda L Kalen; Prabhat C Goswami
Journal:  Antioxid Redox Signal       Date:  2009-12       Impact factor: 8.401

Review 9.  Oxidative stress and immunosenescence: therapeutic effects of melatonin.

Authors:  Javier Espino; José A Pariente; Ana B Rodríguez
Journal:  Oxid Med Cell Longev       Date:  2012-12-31       Impact factor: 6.543

10.  Aging is not senescence: a short computer demonstration and implications for medical practice.

Authors:  Thiago Oliveira Monaco; Paulo Sergio Panse Silveira
Journal:  Clinics (Sao Paulo)       Date:  2009-05       Impact factor: 2.365

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.