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Literature DB >> 10954737

Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity.

M Bocchetta¹, I Di Resta, A Powers, R Fresco, A Tosolini, J R Testa, H I Pass, P Rizzo, M Carbone.

Abstract

Mesothelioma, a malignancy associated with asbestos, has been recently linked to simian virus 40 (SV40). We found that infection of human mesothelial cells by SV40 is very different from the semipermissive infection thought to be characteristic of human cells. Mesothelial cells are uniformly infected but not lysed by SV40, a mechanism related to p53, and undergo cell transformation at an extremely high rate. Exposure of mesothelial cells to asbestos complemented SV40 mutants in transformation. Our data provide a mechanistic explanation for the ability of SV40 to transform mesothelial cells preferentially and indicate that asbestos and SV40 may be cocarcinogens.

Entities: Chemical Disease Species

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Year: 2000 PMID： 10954737 PMCID： PMC27818 DOI： 10.1073/pnas.170207097

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

24 in total

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Journal: Nature Date: 1987 Oct 1-7 Impact factor: 49.962

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Journal: J Virol Date: 1985-02 Impact factor: 5.103

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Journal: Cancer Res Date: 1999-12-15 Impact factor: 12.701

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Authors: P Rizzo; M Carbone; S G Fisher; C Matker; L J Swinnen; A Powers; I Di Resta; S Alkan; H I Pass; R I Fisher
Journal: Chest Date: 1999-12 Impact factor: 9.410

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Journal: J Cell Biochem Date: 1999-12 Impact factor: 4.429

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Journal: Nature Date: 1987 Oct 1-7 Impact factor: 49.962

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Authors: H N Zhen; X Zhang; X Y Bu; Z W Zhang; W J Huang; P Zhang; J W Liang; X L Wang
Journal: Cancer Date: 1999-11-15 Impact factor: 6.860

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Journal: Proc Biol Sci Date: 1991-08-22 Impact factor: 5.349

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Authors: K Dixon; B J Ryder; E Burch-Jaffe
Journal: Nature Date: 1982-04-15 Impact factor: 49.962

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Authors: A Procopio; L Strizzi; G Vianale; P Betta; R Puntoni; V Fontana; G Tassi; F Gareri; L Mutti
Journal: Genes Chromosomes Cancer Date: 2000-10 Impact factor: 5.006

70 in total

1. Simian virus 40 and the human mesothelium.

Authors: G Klein
Journal: Proc Natl Acad Sci U S A Date: 2000-08-29 Impact factor: 11.205

2. Telomerase activity in pleural malignant mesotheliomas.

Authors: Amy Y M Au; Torben Hackl; Thomas R Yeager; Scott B Cohen; Harvey I Pass; Curtis C Harris; Roger R Reddel
Journal: Lung Cancer Date: 2011-01-31 Impact factor: 5.705

3. A one-generation cluster of malignant mesothelioma within a family reveals exposure to asbestos-contaminated jute bags in Naples, Italy.

Authors: V Ascoli; C Carnovale-Scalzo; F Nardi; C Efrati; M Menegozzo
Journal: Eur J Epidemiol Date: 2003 Impact factor: 8.082

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Authors: Robert L Garcea; Michael J Imperiale
Journal: J Virol Date: 2003-05 Impact factor: 5.103

5. Establishment of permanent cell lines purified from human mesothelioma: morphological aspects, new marker expression and karyotypic analysis.

Authors: Marie-Marthe Philippeaux; Jean-Claude Pache; Sophie Dahoun; Marc Barnet; John-Henri Robert; Jacques Mauël; Anastase Spiliopoulos
Journal: Histochem Cell Biol Date: 2004-09-15 Impact factor: 4.304