Promotion of secondary anti-DNP antibody production in mice by type III pneumococcal polysaccharide (SIII) and dinitrophenylated rabbit antibody to SIII.

Type III pneumococcal polysaccharide (SIII) is able markedly to increase the adoptive IgG ANTI-DNP antibody response of B cells primed to DNP-flagellin and stimulated with DNP conjugated to the heterologous carrier, rabbit globulin, provided the latter has anti-SIII activity. The stimulatory effect is apparently accessory cell-dependent as well as being unequivocally T cell-dependent. Although no positive evidence is available, the possibility exists that non-specific T-cell activation is involved in the stimulating effect of anti-SIII plus SIII.