Literature DB >> 1095440

Paradoxical glucagon response after stimulation with glucose and arginine in isolated pancreatic sand rat islets.

M Ziegler, H J Hahn, B Ziegler, E Köhler, H Fiedler.   

Abstract

Isolated pancreatic islets of normoglycemic sand rats do not respond to 2.5 mM glucose with an enhanced glucagon secretion, which could be observed in normal Wistar rats. Arginine stimulates glucagon release in the presence of 2.5 mM glucose in Wistar rats as well as in sand rats. The secretion pattern is not caused by insulin deficiency since sand rat islets are characterized by an increased insulin secretion rate in vitro. This paradoxical glucagon secretion is not caused by a changed glucagon content but might be related to this species which is able to develop a diabetic syndrome spontaneously.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 1095440     DOI： 10.1007/bf00422820

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  47 in total

1.  Characterization of the glucagon response to hypoglycemia in man.

Authors:  J E Gerich; V Schneider; S E Dippe; M Langlois; C Noacco; J H Karam; P H Forsham
Journal:  J Clin Endocrinol Metab       Date:  1974-01       Impact factor: 5.958

Review 2.  Effect of amino acids and proteins on insulin secretion in man.

Authors:  S S Fajans; J C Floyd; R F Knopf; F W Conn
Journal:  Recent Prog Horm Res       Date:  1967

3.  Effect of glucose concentration on insulin and glucagon release from isolated islets of Langerhans of the rat.

Authors:  J E Vance; K D Buchanan; D R Challoner; R H Williams
Journal:  Diabetes       Date:  1968-04       Impact factor: 9.461

4.  Stimulation of insulin secretion by noncarbohydrate metabolites.

Authors:  W J Malaisse; F Malaisse-Lagae
Journal:  J Lab Clin Med       Date:  1968-09

5.  The effects of feeding and various hormones on the glucose tolerance of the sand rat (Psammomys obesus).

Authors:  B N Brodoff; J C Penhos; R Levine
Journal:  Diabetologia       Date:  1967-04       Impact factor: 10.122

6.  Stimulation of glucagon secretion by arginine and histidine infused intrapancreatically.

Authors:  A Kaneto; K Kosaka
Journal:  Endocrinology       Date:  1971-05       Impact factor: 4.736

7.  Relationships between arginine and glucose in the induction of insulin secretion from the isolated, perfused rat pancreas.

Authors:  S R Levin; G M Grodsky; R Hagura; D F Smith; P H Forsham
Journal:  Endocrinology       Date:  1972-03       Impact factor: 4.736

8.  [Studies of the Langerhan's islands in vitro. VI. Effect of island size on the insulin secretion].

Authors:  H J Hahn; R Michael; H Kansy
Journal:  Acta Biol Med Ger       Date:  1970

9.  The effect of experimental insulin deficiency on glucagon secretion.

Authors:  W A Müller; G R Faloona; R H Unger
Journal:  J Clin Invest       Date:  1971-09       Impact factor: 14.808

Review 10.  Proinsulin and the biosynthesis of insulin.

Authors:  D F Steiner; J L Clark; C Nolan; A H Rubenstein; E Margoliash; B Aten; P E Oyer
Journal:  Recent Prog Horm Res       Date:  1969
View more
  3 in total

1.  Evaluation of insulin resistance during inhibition of endogenous insulin and glucagon secretion by somatostatin in non-obese subjects with impaired glucose tolerance.

Authors:  K P Ratzmann; W Besch; S Witt; B Schulz
Journal:  Diabetologia       Date:  1981-09       Impact factor: 10.122

2.  Studies on glucagon secretion using isolated islets of Langerhans of the rat.

Authors:  J R Oliver; V L Williams; P H Wright
Journal:  Diabetologia       Date:  1976-08       Impact factor: 10.122

3.  Function of pancreatic endocrine cells in experimental acute pancreatitis.

Authors:  Y Kinami; T Mura; M Sugii; I Miyazaki
Journal:  World J Surg       Date:  1982-07       Impact factor: 3.352
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.