Literature DB >> 10954185

Animal models of exocrine pancreatic cancer.

H G Hotz1, O J Hines, T Foitzik, H A Reber.   

Abstract

Clinically and biologically relevant animal models are mandatory to further evaluate both the pathophysiology and novel strategies for diagnosis and treatment of exocrine pancreatic cancer. This review briefly summarizes the features of human pancreatic cancer in order to define requirements for animal models of the disease. The described model systems in rodents include pancreatic cancer induced by chemicals, pancreatic cancer in transgenic, and immunodeficient animals.

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Year:  2000        PMID： 10954185     DOI： 10.1007/s003840000229

Source DB:  PubMed          Journal:  Int J Colorectal Dis        ISSN： 0179-1958            Impact factor:   2.571


  10 in total

1.  Immunotherapy in new pre-clinical models of HPV-associated oral cancers.

Authors:  Francesca Paolini; Silvia Massa; Isabella Manni; Rosella Franconi; Aldo Venuti
Journal:  Hum Vaccin Immunother       Date:  2013-01-07       Impact factor: 3.452

2.  Immunohistochemical detection of cell growth fraction in formalin-fixed and paraffin-embedded murine tissue.

Authors:  P Birner; M Ritzi; C Musahl; R Knippers; J Gerdes; T Voigtländer; H Budka; J A Hainfellner
Journal:  Am J Pathol       Date:  2001-06       Impact factor: 4.307

3.  Specific targeting of tumor vasculature by diphtheria toxin-vascular endothelial growth factor fusion protein reduces angiogenesis and growth of pancreatic cancer.

Authors:  Hubert G Hotz; Parkash S Gill; Rizwan Masood; Birgit Hotz; Heinz J Buhr; Thomas Foitzik; O Joe Hines; Howard A Reber
Journal:  J Gastrointest Surg       Date:  2002 Mar-Apr       Impact factor: 3.452

4.  VEGF-RII influences the prognosis of pancreatic cancer.

Authors:  Peter Büchler; Howard A Reber; Markus W Büchler; Helmut Friess; Oscar J Hines
Journal:  Ann Surg       Date:  2002-12       Impact factor: 12.969

Review 5.  Histological complexities of pancreatic lesions from transgenic mouse models are consistent with biological and morphological heterogeneity of human pancreatic cancer.

Authors:  J D Liao; N V Adsay; F Khannani; D Grignon; A Thakur; F H Sarkar
Journal:  Histol Histopathol       Date:  2007-06       Impact factor: 2.303

6.  Evaluation of vascular endothelial growth factor blockade and matrix metalloproteinase inhibition as a combination therapy for experimental human pancreatic cancer.

Authors:  Hubert G Hotz; O Joe Hines; Birgit Hotz; Thomas Foitzik; Heinz J Buhr; Howard A Reber
Journal:  J Gastrointest Surg       Date:  2003-02       Impact factor: 3.452

7.  Two-dimensional culture of human pancreatic adenocarcinoma cells results in an irreversible transition from epithelial to mesenchymal phenotype.

Authors:  Ya'an Kang; Ran Zhang; Rei Suzuki; Shao-qiang Li; David Roife; Mark J Truty; Deyali Chatterjee; Ryan M Thomas; James Cardwell; Yu Wang; Huamin Wang; Matthew H Katz; Jason B Fleming
Journal:  Lab Invest       Date:  2014-12-08       Impact factor: 5.662

Review 8.  Experimental animal models of pancreatic carcinogenesis and metastasis.

Authors:  Daoyan Wei; Henry Q Xiong; James L Abbruzzese; Keping Xie
Journal:  Int J Gastrointest Cancer       Date:  2003

9.  Application of 3.0 tesla magnetic resonance imaging for diagnosis in the orthotopic nude mouse model of pancreatic cancer.

Authors:  Li Wu; Chen Wang; Xiuzhong Yao; Kai Liu; Yanjun Xu; Haitao Zhang; Caixia Fu; Xiaolin Wang; Yingyi Li
Journal:  Exp Anim       Date:  2014-07-22

Review 10.  Patient-Derived Xenograft Models of Pancreatic Cancer: Overview and Comparison with Other Types of Models.

Authors:  Patrick L Garcia; Aubrey L Miller; Karina J Yoon
Journal:  Cancers (Basel)       Date:  2020-05-22       Impact factor: 6.639
  10 in total

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