METHODS: The records of 106 children aged less than 5 years with invasive disease caused by Streptococcus pneumoniae were reviewed. RESULTS: The clinical manifestations were meningitis (37%), upper respiratory tract infection (24%), pneumonia (19%), and occult bacteraemia (18%). One child died and seven had persisting neurological impairment. Five serotypes caused 83% of disease and 92% of the serotypes are included in the seven valent conjugate vaccines which are undergoing trials. CONCLUSIONS: These data suggest that S pneumoniae infection is associated with a low case fatality rate but substantial morbidity in the UK.
METHODS: The records of 106 children aged less than 5 years with invasive disease caused by Streptococcus pneumoniae were reviewed. RESULTS: The clinical manifestations were meningitis (37%), upper respiratory tract infection (24%), pneumonia (19%), and occult bacteraemia (18%). One child died and seven had persisting neurological impairment. Five serotypes caused 83% of disease and 92% of the serotypes are included in the seven valent conjugate vaccines which are undergoing trials. CONCLUSIONS: These data suggest that S pneumoniae infection is associated with a low case fatality rate but substantial morbidity in the UK.
Authors: A Schuchat; K Robinson; J D Wenger; L H Harrison; M Farley; A L Reingold; L Lefkowitz; B A Perkins Journal: N Engl J Med Date: 1997-10-02 Impact factor: 91.245
Authors: K B Laupland; H D Davies; J D Kellner; N L Luzod; T Karan; D Ma; D Taub; C Nijssen-Jordan; G Katzko; T Jadavji; D Church Journal: Clin Infect Dis Date: 1998-09 Impact factor: 9.079
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