Literature DB >> 10952626

Characterization of a genetic element carrying the macrolide efflux gene mef(A) in Streptococcus pneumoniae.

M Santagati1, F Iannelli, M R Oggioni, S Stefani, G Pozzi.   

Abstract

The mef(A) gene from a clinical isolate of Streptococcus pneumoniae exhibiting the M-type resistance to macrolides was found to be part of the 7,244-bp chromosomal element Tn1207.1, which contained 8 open reading frames. orf2 encodes a resolvase/invertase, and orf5 is a homolog of the macrolide-streptogramin B resistance gene msr(SA).

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Year:  2000        PMID： 10952626      PMCID： PMC90116          DOI： 10.1128/AAC.44.9.2585-2587.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  41 in total

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Journal:  Nucleic Acids Res       Date:  1997-09-01       Impact factor: 16.971

2.  Characterization of the ends and target sites of the novel conjugative transposon Tn5397 from Clostridium difficile: excision and circularization is mediated by the large resolvase, TndX.

Authors:  H Wang; A P Roberts; D Lyras; J I Rood; M Wilks; P Mullany
Journal:  J Bacteriol       Date:  2000-07       Impact factor: 3.490

3.  Complete nucleotide sequence of a skin element excised by DNA rearrangement during sporulation in Bacillus subtilis.

Authors:  K Takemaru; M Mizuno; T Sato; M Takeuchi; Y Kobayashi
Journal:  Microbiology       Date:  1995-02       Impact factor: 2.777

4.  Novel mechanism of macrolide resistance in Streptococcus pneumoniae.

Authors:  V D Shortridge; R K Flamm; N Ramer; J Beyer; S K Tanaka
Journal:  Diagn Microbiol Infect Dis       Date:  1996-10       Impact factor: 2.803

5.  Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenes.

Authors:  J Clancy; J Petitpas; F Dib-Hajj; W Yuan; M Cronan; A V Kamath; J Bergeron; J A Retsema
Journal:  Mol Microbiol       Date:  1996-12       Impact factor: 3.501

6.  The resolvase/invertase domain of the site-specific recombinase TnpX is functional and recognizes a target sequence that resembles the junction of the circular form of the Clostridium perfringens transposon Tn4451.

Authors:  P K Crellin; J I Rood
Journal:  J Bacteriol       Date:  1997-08       Impact factor: 3.490

7.  mefE is necessary for the erythromycin-resistant M phenotype in Streptococcus pneumoniae.

Authors:  A Tait-Kamradt; J Clancy; M Cronan; F Dib-Hajj; L Wondrack; W Yuan; J Sutcliffe
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

8.  Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system.

Authors:  J Sutcliffe; A Tait-Kamradt; L Wondrack
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191

9.  Competence for genetic transformation in encapsulated strains of Streptococcus pneumoniae: two allelic variants of the peptide pheromone.

Authors:  G Pozzi; L Masala; F Iannelli; R Manganelli; L S Havarstein; L Piccoli; D Simon; D A Morrison
Journal:  J Bacteriol       Date:  1996-10       Impact factor: 3.490

10.  Molecular genetics of the chloramphenicol-resistance transposon Tn4451 from Clostridium perfringens: the TnpX site-specific recombinase excises a circular transposon molecule.

Authors:  T L Bannam; P K Crellin; J I Rood
Journal:  Mol Microbiol       Date:  1995-05       Impact factor: 3.501
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  55 in total

1.  The macrolide efflux genetic assembly of Streptococcus pneumoniae is present in erythromycin-resistant Streptococcus salivarius.

Authors:  Christina Stadler; Michael Teuber
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

2.  Resistance to macrolides and related antibiotics in Streptococcus pneumoniae.

Authors:  Roland Leclercq; Patrice Courvalin
Journal:  Antimicrob Agents Chemother       Date:  2002-09       Impact factor: 5.191

3.  Phenotypes and genotypes of erythromycin-resistant pneumococci in Italy.

Authors:  Maria Pia Montanari; Marina Mingoia; Ileana Cochetti; Pietro Emanuele Varaldo
Journal:  J Clin Microbiol       Date:  2003-01       Impact factor: 5.948

4.  A newly discovered Bacteroides conjugative transposon, CTnGERM1, contains genes also found in gram-positive bacteria.

Authors:  Yanping Wang; Gui-Rong Wang; Aikiesha Shelby; Nadja B Shoemaker; Abigail A Salyers
Journal:  Appl Environ Microbiol       Date:  2003-08       Impact factor: 4.792

5.  Evolution and global dissemination of macrolide-resistant group A streptococci.

Authors:  D Ashley Robinson; Joyce A Sutcliffe; Wezenet Tewodros; Anand Manoharan; Debra E Bessen
Journal:  Antimicrob Agents Chemother       Date:  2006-09       Impact factor: 5.191

6.  Prevalence and molecular analysis of macrolide and fluoroquinolone resistance among isolates of Streptococcus pneumoniae collected during the 2000-2001 PROTEKT US Study.

Authors:  Steven D Brown; David J Farrell; Ian Morrissey
Journal:  J Clin Microbiol       Date:  2004-11       Impact factor: 5.948

7.  Prevalence and molecular genetics of macrolide resistance among Streptococcus pneumoniae isolates collected in Finland in 2002.

Authors:  M Rantala; S Huikko; P Huovinen; J Jalava
Journal:  Antimicrob Agents Chemother       Date:  2005-10       Impact factor: 5.191

Review 8.  Molecular detection of the macrolide efflux gene: to discriminate or not to discriminate between mef(A) and mef(E).

Authors:  Corné H W Klaassen; Johan W Mouton
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

9.  Distribution of mef(A) in gram-positive bacteria from healthy Portuguese children.

Authors:  Vicki A Luna; Marc Heiken; Kathleen Judge; Catherine Ulep; Nicole Van Kirk; Henrique Luis; Mario Bernardo; Jose Leitao; Marilyn C Roberts
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

Review 10.  Resistance to Macrolide Antibiotics in Public Health Pathogens.

Authors:  Corey Fyfe; Trudy H Grossman; Kathy Kerstein; Joyce Sutcliffe
Journal:  Cold Spring Harb Perspect Med       Date:  2016-10-03       Impact factor: 6.915
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