Literature DB >> 10952617

In vitro activity of trovafloxacin compared to those of five antimicrobials against mycoplasmas including Mycoplasma hominis and Ureaplasma urealyticum fluoroquinolone-resistant isolates that have been genetically characterized.

C M Bebear1, H Renaudin, A Charron, D Gruson, M Lefrancois, C Bebear.   

Abstract

The in vitro activity of trovafloxacin against 125 strains of Mycoplasma species and Ureaplasma urealyticum, including fluoroquinolone-susceptible and fluoroquinolone-resistant species, was compared to those of other fluoroquinolones, doxycycline, and erythromycin. The MIC at which 90% of isolates are inhibited for all fluoroquinolone-susceptible strains was 0.25 microg/ml. Whatever the associated mutations, trovafloxacin exhibited greater activity than the other fluoroquinolones tested against fluoroquinolone-resistant Mycoplasma hominis and U. urealyticum isolates.

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Year:  2000        PMID： 10952617      PMCID： PMC90107          DOI： 10.1128/AAC.44.9.2557-2560.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  In-vitro activity of trovafloxacin, a new fluoroquinolone, against recent clinical isolates.

Authors:  D Felmingham; M J Robbins; K Ingley; I Mathias; H Bhogal; A Leakey; G L Ridgway; R N Grüneberg
Journal:  J Antimicrob Chemother       Date:  1997-06       Impact factor: 5.790

2.  Susceptibilities of Mycoplasma pneumoniae, Mycoplasma hominis, and Ureaplasma urealyticum to a new quinolone, trovafloxacin (CP-99,219).

Authors:  G E Kenny; F D Cartwright
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

3.  In vitro activity of BAY 12-8039, a new fluoroquinolone against mycoplasmas.

Authors:  C M Bébéar; H Renaudin; A Boudjadja; C Bébéar
Journal:  Antimicrob Agents Chemother       Date:  1998-03       Impact factor: 5.191

4.  In-vitro activity of grepafloxacin, a new fluoroquinolone, against mycoplasmas.

Authors:  C M Bébéar; H Renaudin; T Schaeverbeke; F Leblanc; C Bébéar
Journal:  J Antimicrob Chemother       Date:  1999-05       Impact factor: 5.790

5.  Alterations in topoisomerase IV and DNA gyrase in quinolone-resistant mutants of Mycoplasma hominis obtained in vitro.

Authors:  C M Bébéar; H Renaudin; A Charron; J M Bové; C Bébéar; J Renaudin
Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191

6.  Mutations in the gyrA, parC, and parE genes associated with fluoroquinolone resistance in clinical isolates of Mycoplasma hominis.

Authors:  C M Bebear; J Renaudin; A Charron; H Renaudin; B de Barbeyrac; T Schaeverbeke; C Bebear
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

7.  Characterization of Mycoplasma hominis mutations involved in resistance to fluoroquinolones.

Authors:  C M Bebear; J M Bové; C Bebear; J Renaudin
Journal:  Antimicrob Agents Chemother       Date:  1997-02       Impact factor: 5.191

8.  In vitro activity of the new fluoroquinolone CP-99,219.

Authors:  H C Neu; N X Chin
Journal:  Antimicrob Agents Chemother       Date:  1994-11       Impact factor: 5.191

Review 9.  Bacterial topoisomerases, anti-topoisomerases, and anti-topoisomerase resistance.

Authors:  D C Hooper
Journal:  Clin Infect Dis       Date:  1998-08       Impact factor: 9.079
  9 in total
  25 in total

1.  Characterization of mutations in DNA gyrase and topoisomerase IV Involved in quinolone resistance of Mycoplasma gallisepticum mutants obtained in vitro.

Authors:  A K Reinhardt; C M Bébéar; M Kobisch; I Kempf; A V Gautier-Bouchardon
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

2.  DNA gyrase and topoisomerase IV mutations in clinical isolates of Ureaplasma spp. and Mycoplasma hominis resistant to fluoroquinolones.

Authors:  C M Bébéar; H Renaudin; A Charron; M Clerc; S Pereyre; C Bébéar
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

3.  Ureaplasma urealyticum meningitis in an adult patient.

Authors:  Walter Geissdörfer; Günter Sandner; Stefan John; André Gessner; Christoph Schoerner; Klaus Schröppel
Journal:  J Clin Microbiol       Date:  2008-01-03       Impact factor: 5.948

4.  Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101.

Authors:  Ken B Waites; D M Crabb; Lynn B Duffy
Journal:  Antimicrob Agents Chemother       Date:  2009-03-02       Impact factor: 5.191

5.  In vitro activity of five quinolones and analysis of the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum clinical isolates from perinatal patients in Japan.

Authors:  Yasuhiro Kawai; Yukiko Nakura; Tetsu Wakimoto; Makoto Nomiyama; Tsugumichi Tokuda; Toshimitsu Takayanagi; Jun Shiraishi; Kenshi Wasada; Hiroyuki Kitajima; Tomio Fujita; Masahiro Nakayama; Nobuaki Mitsuda; Isao Nakanishi; Makoto Takeuchi; Itaru Yanagihara
Journal:  Antimicrob Agents Chemother       Date:  2015-02-02       Impact factor: 5.191

6.  Cloning and nucleotide sequence of the DNA gyrase (gyrA) gene from Mycoplasma hominis and characterization of quinolone-resistant mutants selected in vitro with trovafloxacin.

Authors:  C M Bébéar; O Grau; A Charron; H Renaudin; D Gruson; C Bébéar
Journal:  Antimicrob Agents Chemother       Date:  2000-10       Impact factor: 5.191

7.  Chromosomal mutations responsible for fluoroquinolone resistance in Ureaplasma species in the United States.

Authors:  Li Xiao; Donna M Crabb; Lynn B Duffy; Vanya Paralanov; John I Glass; Ken B Waites
Journal:  Antimicrob Agents Chemother       Date:  2012-02-27       Impact factor: 5.191

8.  Antimicrobial Susceptibility and Clonality of Clinical Ureaplasma Isolates in the United States.

Authors:  Javier Fernández; Melissa J Karau; Scott A Cunningham; Kerryl E Greenwood-Quaintance; Robin Patel
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

9.  Antibacterial Resistance in Ureaplasma Species and Mycoplasma hominis Isolates from Urine Cultures in College-Aged Females.

Authors:  Marissa A Valentine-King; Mary B Brown
Journal:  Antimicrob Agents Chemother       Date:  2017-09-22       Impact factor: 5.191

10.  Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance.

Authors:  Michael L Beeton; Victoria J Chalker; Nicola C Maxwell; Sailesh Kotecha; O Brad Spiller
Journal:  Antimicrob Agents Chemother       Date:  2009-03-09       Impact factor: 5.191
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