BACKGROUND: The aim of the study is to investigate the development of subjective and objective findings during the first two years after DVT (deep venous thrombosis). METHODS: This prospective two-year follow-up study was established in Tampere University Hospital in Finland. Twenty-six patients with a two-year follow-up after a phlebographically confirmed DVT were followed. Patients were treated conventionally with heparin and warfarin. Phlebography was repeated 7 months after DVT. Color-flow duplex imaging (CFDI) was performed in both legs 7 and 20 months after DVT. The subjective symptoms in both legs were recorded at the beginning and at the end of the follow-up. The development of venous reflux, obstruction and subjective symptoms after DVT were studied. RESULTS: 50% of the legs with DVT had a pathological (deep reflux or obstructive change) CFDI-finding in the popliteal segment after a 20-month follow-up. The pathological findings in the control legs were rare. The rate of recanalisation was high. There was no difference between calf and more proximal DVTs. Pain (62%), oedema (46%) and pigmentation (35%) were common and only 27% of the legs with DVT were asymptomatic. CONCLUSIONS: The development of the post-thrombotic syndrome begins quite early. The frequency of the subjective symptoms is high. Calf DVT may lead to postthrombotic sequelae in the popliteal segment.
BACKGROUND: The aim of the study is to investigate the development of subjective and objective findings during the first two years after DVT (deep venous thrombosis). METHODS: This prospective two-year follow-up study was established in Tampere University Hospital in Finland. Twenty-six patients with a two-year follow-up after a phlebographically confirmed DVT were followed. Patients were treated conventionally with heparin and warfarin. Phlebography was repeated 7 months after DVT. Color-flow duplex imaging (CFDI) was performed in both legs 7 and 20 months after DVT. The subjective symptoms in both legs were recorded at the beginning and at the end of the follow-up. The development of venous reflux, obstruction and subjective symptoms after DVT were studied. RESULTS: 50% of the legs with DVT had a pathological (deep reflux or obstructive change) CFDI-finding in the popliteal segment after a 20-month follow-up. The pathological findings in the control legs were rare. The rate of recanalisation was high. There was no difference between calf and more proximal DVTs. Pain (62%), oedema (46%) and pigmentation (35%) were common and only 27% of the legs with DVT were asymptomatic. CONCLUSIONS: The development of the post-thrombotic syndrome begins quite early. The frequency of the subjective symptoms is high. Calf DVT may lead to postthrombotic sequelae in the popliteal segment.
Authors: Elham E Amin; Ingrid M Bistervels; Karina Meijer; Lidwine W Tick; Saskia Middeldorp; Guy Mostard; Marlène van de Poel; Erik H Serné; Hans M Otten; Edith M Klappe; Manuela A Joore; Hugo Ten Cate; Marije Ten Wolde; Arina J Ten Cate-Hoek Journal: Blood Date: 2018-09-20 Impact factor: 22.113
Authors: Prakash Saha; Marcelo E Andia; Bijan Modarai; Ulrike Blume; Julia Humphries; Ashish S Patel; Alkystis Phinikaridou; Colin E Evans; Katherine Mattock; Steven P Grover; Anwar Ahmad; Oliver T Lyons; Rizwan Q Attia; Thomas Renné; Sobath Premaratne; Andrea J Wiethoff; René M Botnar; Tobias Schaeffter; Matthew Waltham; Alberto Smith Journal: Circulation Date: 2013-07-02 Impact factor: 29.690
Authors: Colin E Evans; Julia Humphries; Matthew Waltham; Prakash Saha; Katherine Mattock; Ashish Patel; Anwar Ahmad; Ashar Wadoodi; Bijan Modarai; Kevin Burnand; Alberto Smith Journal: Thromb Res Date: 2011-05-31 Impact factor: 3.944
Authors: G C Mol; M A van de Ree; F A Klok; M J A M Tegelberg; F B M Sanders; S Koppen; O de Weerdt; T Koster; M M C Hovens; H A H Kaasjager; R E Brouwer; E Kragten; C G Schaar; W Spiering; W P Arnold; D H Biesma; M V Huisman Journal: BMJ Date: 2016-05-31
Authors: Prakash Saha; Julia Humphries; Bijan Modarai; Katherine Mattock; Matthew Waltham; Colin E Evans; Anwar Ahmad; Ashish S Patel; Sobath Premaratne; Oliver T A Lyons; Alberto Smith Journal: Arterioscler Thromb Vasc Biol Date: 2011-03 Impact factor: 8.311