Literature DB >> 10952080

Ca2+-independent phospholipase A2 inhibitor impairs spatial memory of mice.

S Fujita1, Y Ikegaya, N Nishiyama, N Matsuki.   

Abstract

Pharmacological blockade of Ca2+-independent phospholipase A2 (PLA2) is reported to disintegrate hippocampal synaptic plasticity, which is thought to be the cellular mechanism underlying learning and memory. Therefore, we investigated the effect of the Ca2+-independent PLA2 inhibitor bromoenol lactone (BEL) on spontaneous alteration behaviors of mice. When 3 nmol BEL was intracerebroventricularly injected 30 min prior to the test, the mice showed a poor alternation ratio, compared with control animals. The data suggest that Ca2+-independent PLA2 activity is required for spatial memory.

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Year:  2000        PMID： 10952080     DOI： 10.1254/jjp.83.277

Source DB:  PubMed          Journal:  Jpn J Pharmacol        ISSN： 0021-5198


  16 in total

1.  Decreased phospholipase A2 activity in cerebrospinal fluid of patients with dementia.

Authors:  Stefan Smesny; Susan Stein; Ingo Willhardt; Jürgen Lasch; Heinrich Sauer
Journal:  J Neural Transm (Vienna)       Date:  2008-06-27       Impact factor: 3.575

2.  Requirement of hippocampal phospholipase A2 activity for long-term memory retrieval in rats.

Authors:  E L Schaeffer; W F Gattaz
Journal:  J Neural Transm (Vienna)       Date:  2006-10-27       Impact factor: 3.575

3.  Imaging decreased brain docosahexaenoic acid metabolism and signaling in iPLA(2)β (VIA)-deficient mice.

Authors:  Mireille Basselin; Angelo O Rosa; Epolia Ramadan; Yewon Cheon; Lisa Chang; Mei Chen; Deanna Greenstein; Mary Wohltmann; John Turk; Stanley I Rapoport
Journal:  J Lipid Res       Date:  2010-08-04       Impact factor: 5.922

4.  Inhibition of calcium-independent phospholipase A2 activity in rat hippocampus impairs acquisition of short- and long-term memory.

Authors:  Evelin L Schaeffer; Wagner F Gattaz
Journal:  Psychopharmacology (Berl)       Date:  2005-10-14       Impact factor: 4.530

5.  Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices.

Authors:  S Fujita; Y Ikegaya; M Nishikawa; N Nishiyama; N Matsuki
Journal:  Br J Pharmacol       Date:  2001-04       Impact factor: 8.739

Review 6.  The role of phospholipase A2 in neuronal homeostasis and memory formation: implications for the pathogenesis of Alzheimer's disease.

Authors:  O V Forlenza; E L Schaeffer; W F Gattaz
Journal:  J Neural Transm (Vienna)       Date:  2006-11-27       Impact factor: 3.575

Review 7.  Phospholipase A2 and arachidonic acid in Alzheimer's disease.

Authors:  Rene O Sanchez-Mejia; Lennart Mucke
Journal:  Biochim Biophys Acta       Date:  2010-05-27

8.  Conjugated linoleic acid-enriched butter improved memory and up-regulated phospholipase A2 encoding-genes in rat brain tissue.

Authors:  Marco A S Gama; Nádia R B Raposo; Fábio B Mury; Fernando C F Lopes; Emmanuel Dias-Neto; Leda L Talib; Wagner F Gattaz
Journal:  J Neural Transm (Vienna)       Date:  2015-04-26       Impact factor: 3.575

Review 9.  Phospholipase A2 activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease.

Authors:  Evelin L Schaeffer; Orestes V Forlenza; Wagner F Gattaz
Journal:  Psychopharmacology (Berl)       Date:  2008-10-14       Impact factor: 4.530

10.  Conditioning training and retrieval increase phospholipase A(2) activity in the cerebral cortex of rats.

Authors:  E L Schaeffer; L Zorrón Pu; D A M Gagliotti; W F Gattaz
Journal:  J Neural Transm (Vienna)       Date:  2008-11-04       Impact factor: 3.575
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