Literature DB >> 10950930

Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene.

T Muto1, M Muramatsu, M Taniwaki, K Kinoshita, T Honjo.   

Abstract

The gene encoding activation-induced cytidine deaminase (AID), a member of the cytidine deaminase family, was isolated from a murine B cell lymphoma line, CH12F3-2, induced by combined stimulation of TGF-beta, IL-4, and CD40L. We have isolated the human orthologue of mouse AID cDNA, which has an open reading frame of 198 residues containing a conserved cytidine deaminase motif. The amino acid sequence of human AID is 92% identical to that of mouse AID. RT-PCR analysis of 15 human tissues showed that AID mRNA is expressed strongly in lymph nodes and tonsils. The complete human AID gene consisting of five exons was isolated and mapped to chromosome 12p13 by fluorescence in situ hybridization. Copyright 2000 Academic Press.

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Year:  2000        PMID： 10950930     DOI： 10.1006/geno.2000.6268

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  30 in total

Review 1.  Functions and regulation of the APOBEC family of proteins.

Authors:  Harold C Smith; Ryan P Bennett; Ayse Kizilyer; William M McDougall; Kimberly M Prohaska
Journal:  Semin Cell Dev Biol       Date:  2011-10-06       Impact factor: 7.727

2.  The cytidine deaminases AID and APOBEC-1 exhibit distinct functional properties in a novel yeast selectable system.

Authors:  Kristina Krause; Kenneth B Marcu; Jobst Greeve
Journal:  Mol Immunol       Date:  2005-06-15       Impact factor: 4.407

Review 3.  The dark side of activation-induced cytidine deaminase: relationship with leukemia and beyond.

Authors:  Kazuo Kinoshita; Taichiro Nonaka
Journal:  Int J Hematol       Date:  2006-04       Impact factor: 2.490

4.  Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.

Authors:  Ai Kotani; Naoki Kakazu; Tatsuaki Tsuruyama; Il-mi Okazaki; Masamichi Muramatsu; Kazuo Kinoshita; Hitoshi Nagaoka; Daisuke Yabe; Tasuku Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-24       Impact factor: 11.205

Review 5.  Evaluation of molecular models for the affinity maturation of antibodies: roles of cytosine deamination by AID and DNA repair.

Authors:  Mala Samaranayake; Janusz M Bujnicki; Michael Carpenter; Ashok S Bhagwat
Journal:  Chem Rev       Date:  2006-02       Impact factor: 60.622

Review 6.  CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes.

Authors:  A Bhushan; L R Covey
Journal:  Immunol Res       Date:  2001       Impact factor: 2.829

7.  NF-IL6 (C/EBPbeta) induces HIV-1 replication by inhibiting cytidine deaminase APOBEC3G.

Authors:  Shigemi M Kinoshita; Shizuka Taguchi
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-22       Impact factor: 11.205

8.  Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome.

Authors:  Masayuki Kuraoka; Dongmei Liao; Kaiyong Yang; Sallie D Allgood; Marc C Levesque; Garnett Kelsoe; Yoshihiro Ueda
Journal:  J Immunol       Date:  2009-08-10       Impact factor: 5.422

9.  GADD45A protein plays an essential role in active DNA demethylation during terminal osteogenic differentiation of adipose-derived mesenchymal stem cells.

Authors:  Rui-peng Zhang; Jian-zhong Shao; Li-xin Xiang
Journal:  J Biol Chem       Date:  2011-09-14       Impact factor: 5.157

10.  A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif).

Authors:  Bärbel Schröfelbauer; Darlene Chen; Nathaniel R Landau
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-20       Impact factor: 11.205
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