Literature DB >> 10949113

Synergistic effect of amantadine and imipramine in the forced swimming test.

J Maj1, Z Rogóz.   

Abstract

The obtained results indicate that joint administration of amantadine (a non-competitive NMDA receptor antagonist) and imipramine induced antidepressant-like effect in the forced swimming test even at doses of both drugs which were ineffective when each of the drugs was used alone.

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Year:  2000        PMID: 10949113

Source DB:  PubMed          Journal:  Pol J Pharmacol        ISSN: 1230-6002


  3 in total

Review 1.  Targeting the glutamatergic system to treat major depressive disorder: rationale and progress to date.

Authors:  Daniel C Mathews; Ioline D Henter; Carlos A Zarate
Journal:  Drugs       Date:  2012-07-09       Impact factor: 9.546

2.  Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular 5-HT in the frontal cortex of freely moving rats.

Authors:  Jenny C E Owen; Peter S Whitton
Journal:  Br J Pharmacol       Date:  2005-07       Impact factor: 8.739

Review 3.  Glutamate and depression: Reflecting a deepening knowledge of the gut and brain effects of a ubiquitous molecule.

Authors:  Adejoke Yetunde Onaolapo; Olakunle James Onaolapo
Journal:  World J Psychiatry       Date:  2021-07-19
  3 in total

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