Literature DB >> 10948185

Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice.

L B Adams1, C K Job, J L Krahenbuhl.   

Abstract

The manifestation of leprosy in humans is largely determined by host immunity to Mycobacterium leprae and is a model for immunoregulation in a human disease. However, animal models available for exploration of the leprosy spectrum are inadequate. This study explored M. leprae infection in mice deficient in inducible nitric oxide synthase, and this report describes elements resembling borderline tuberculoid leprosy in humans.

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Year:  2000        PMID： 10948185      PMCID： PMC101819          DOI： 10.1128/IAI.68.9.5462-5465.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

1.  Inhibition of metabolism and growth of Mycobacterium leprae by gamma irradiation.

Authors:  L B Adams; N A Soileau; J R Battista; J L Krahenbuhl
Journal:  Int J Lepr Other Mycobact Dis       Date:  2000-03

2.  A method for counting acid-fast bacteria.

Authors:  C C Shepard; D H McRae
Journal:  Int J Lepr Other Mycobact Dis       Date:  1968 Jan-Mar

3.  NOS2-derived nitric oxide regulates the size, quantity and quality of granuloma formation in Mycobacterium avium-infected mice without affecting bacterial loads.

Authors:  S Ehlers; S Kutsch; J Benini; A Cooper; C Hahn; J Gerdes; I Orme; C Martin; E T Rietschel
Journal:  Immunology       Date:  1999-11       Impact factor: 7.397

4.  Improved clearance of Mycobacterium avium upon disruption of the inducible nitric oxide synthase gene.

Authors:  M S Gomes; M Flórido; T F Pais; R Appelberg
Journal:  J Immunol       Date:  1999-06-01       Impact factor: 5.422

5.  Growth of Mycobacterium leprae and M. marinum in congenitally athymic (nude) mice.

Authors:  M J Colston; G R Hilson
Journal:  Nature       Date:  1976-07-29       Impact factor: 49.962

6.  The growth of Mycobacterium leprae in nude mice.

Authors:  S Chehl; J Ruby; C K Job; R C Hastings
Journal:  Lepr Rev       Date:  1983-12       Impact factor: 0.537

7.  L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae.

Authors:  L B Adams; S G Franzblau; Z Vavrin; J B Hibbs; J L Krahenbuhl
Journal:  J Immunol       Date:  1991-09-01       Impact factor: 5.422

8.  Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates.

Authors:  M Denis
Journal:  Cell Immunol       Date:  1991-01       Impact factor: 4.868

9.  Effects of activated macrophages on Mycobacterium leprae.

Authors:  N Ramasesh; L B Adams; S G Franzblau; J L Krahenbuhl
Journal:  Infect Immun       Date:  1991-09       Impact factor: 3.441

10.  Urinary nitrate excretion in relation to murine macrophage activation. Influence of dietary L-arginine and oral NG-monomethyl-L-arginine.

Authors:  D L Granger; J B Hibbs; L M Broadnax
Journal:  J Immunol       Date:  1991-02-15       Impact factor: 5.422
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  7 in total

1.  Murine experimental leprosy: Evaluation of immune response by analysis of peritoneal lavage cells and footpad histopathology.

Authors:  Fátima Regina Vilani-Moreno; Adriana Sierra Assêncio Almeida Barbosa; Beatriz Gomes Carreira Sartori; Suzana Madeira Diório; Sônia Maria Usó Ruiz Silva; Patrícia Sammarco Rosa; Andréa de Faria Fernandes Belone; Cleverson Teixeira Soares; José Roberto Pereira Lauris; Sílvia Cristina Barboza Pedrini
Journal:  Int J Exp Pathol       Date:  2019-05-24       Impact factor: 1.925

Review 2.  The continuing challenges of leprosy.

Authors:  D M Scollard; L B Adams; T P Gillis; J L Krahenbuhl; R W Truman; D L Williams
Journal:  Clin Microbiol Rev       Date:  2006-04       Impact factor: 26.132

3.  Effects of thalidomide on intracellular Mycobacterium leprae in normal and activated macrophages.

Authors:  A Tadesse; E J Shannon
Journal:  Clin Diagn Lab Immunol       Date:  2005-01

4.  Antigen-specific cellular and humoral responses are induced by intradermal Mycobacterium leprae infection of the mouse ear.

Authors:  Malcolm S Duthie; Stephen T Reece; Ramanuj Lahiri; Wakako Goto; Vanitha S Raman; Juliette Kaplan; Greg C Ireton; Sylvie Bertholet; Thomas P Gillis; James L Krahenbuhl; Steven G Reed
Journal:  Infect Immun       Date:  2007-08-27       Impact factor: 3.441

5.  Lymphotoxin-alpha and TNF have essential but independent roles in the evolution of the granulomatous response in experimental leprosy.

Authors:  Deanna A Hagge; Bernadette M Saunders; Gigi J Ebenezer; Nashone A Ray; Vilma T Marks; Warwick J Britton; James L Krahenbuhl; Linda B Adams
Journal:  Am J Pathol       Date:  2009-02-26       Impact factor: 4.307

6.  Expression and characterization of recombinant interferon gamma (IFN-gamma) from the nine-banded armadillo (Dasypus novemcinctus) and its effect on Mycobacterium leprae-infected macrophages.

Authors:  M T Peña; J E Adams; L B Adams; T P Gillis; D L Williams; J S Spencer; J L Krahenbuhl; R W Truman
Journal:  Cytokine       Date:  2008-06-16       Impact factor: 3.861

7.  IL-10 and NOS2 modulate antigen-specific reactivity and nerve infiltration by T cells in experimental leprosy.

Authors:  Deanna A Hagge; David M Scollard; Nashone A Ray; Vilma T Marks; Angelina T Deming; John S Spencer; Linda B Adams
Journal:  PLoS Negl Trop Dis       Date:  2014-09-11
  7 in total

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