Literature DB >> 10948173

Regulation of human beta-defensins by gastric epithelial cells in response to infection with Helicobacter pylori or stimulation with interleukin-1.

D A O'Neil1, S P Cole, E Martin-Porter, M P Housley, L Liu, T Ganz, M F Kagnoff.   

Abstract

Gastric epithelial cells in vitro and in vivo are shown to constitutively express the peptide antibiotic human beta-defensin type 1 (hBD-1). In contrast, hBD-2 expression is regulated in gastric epithelial cells and increases in response to infection with Helicobacter pylori or stimulation with the proinflammatory cytokine interleukin-1. These data suggest that hBD-2 is a component of the regulated host gastric epithelial cell response to H. pylori infection and proinflammatory mediators.

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Year:  2000        PMID： 10948173      PMCID： PMC101807          DOI： 10.1128/IAI.68.9.5412-5415.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  25 in total

1.  Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation.

Authors:  L Liu; L Wang; H P Jia; C Zhao; H H Heng; B C Schutte; P B McCray; T Ganz
Journal:  Gene       Date:  1998-11-19       Impact factor: 3.688

Review 2.  Helicobacter pylori and gastric inflammation.

Authors:  K Bodger; J E Crabtree
Journal:  Br Med Bull       Date:  1998       Impact factor: 4.291

3.  Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands.

Authors:  M Mathews; H P Jia; J M Guthmiller; G Losh; S Graham; G K Johnson; B F Tack; P B McCray
Journal:  Infect Immun       Date:  1999-06       Impact factor: 3.441

4.  Identification of human beta-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia.

Authors:  T Hiratsuka; M Nakazato; Y Date; J Ashitani; T Minematsu; N Chino; S Matsukura
Journal:  Biochem Biophys Res Commun       Date:  1998-08-28       Impact factor: 3.575

5.  Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis.

Authors:  S Fu; K S Ramanujam; A Wong; G T Fantry; C B Drachenberg; S P James; S J Meltzer; K T Wilson
Journal:  Gastroenterology       Date:  1999-06       Impact factor: 22.682

Review 6.  Human beta-defensin-2.

Authors:  J M Schröder; J Harder
Journal:  Int J Biochem Cell Biol       Date:  1999-06       Impact factor: 5.085

7.  Human beta-defensin-1: an antimicrobial peptide of urogenital tissues.

Authors:  E V Valore; C H Park; A J Quayle; K R Wiles; P B McCray; T Ganz
Journal:  J Clin Invest       Date:  1998-04-15       Impact factor: 14.808

8.  Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs.

Authors:  R Bals; X Wang; R L Meegalla; S Wattler; D J Weiner; M C Nehls; J M Wilson
Journal:  Infect Immun       Date:  1999-07       Impact factor: 3.441

9.  Local cytokine response in Helicobacter pylori-infected subjects.

Authors:  C Lindholm; M Quiding-Järbrink; H Lönroth; A Hamlet; A M Svennerholm
Journal:  Infect Immun       Date:  1998-12       Impact factor: 3.441

10.  Production of beta-defensins by human airway epithelia.

Authors:  P K Singh; H P Jia; K Wiles; J Hesselberth; L Liu; B A Conway; E P Greenberg; E V Valore; M J Welsh; T Ganz; B F Tack; P B McCray
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-08       Impact factor: 11.205
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  33 in total

1.  Interleukin-8-derived peptide has antibacterial activity.

Authors:  Ase Björstad; Huamei Fu; Anna Karlsson; Claes Dahlgren; Johan Bylund
Journal:  Antimicrob Agents Chemother       Date:  2005-09       Impact factor: 5.191

Review 2.  Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine.

Authors:  Andre J Ouellette
Journal:  Springer Semin Immunopathol       Date:  2005-06-02

3.  Implications of the innate immune response to adenovirus and adenoviral vectors.

Authors:  Seth M Gregory; Shoab A Nazir; Jordan P Metcalf
Journal:  Future Virol       Date:  2011-03       Impact factor: 1.831

4.  Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity.

Authors:  F Bauer; K Schweimer; E Klüver; J R Conejo-Garcia; W G Forssmann; P Rösch; K Adermann; H Sticht
Journal:  Protein Sci       Date:  2001-12       Impact factor: 6.725

5.  β-Defensin-2 is overexpressed in human vocal cord polyps.

Authors:  Jinjin Gu; Yongwang Huang
Journal:  Eur Arch Otorhinolaryngol       Date:  2016-09-01       Impact factor: 2.503

6.  Modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression during gastritis.

Authors:  M Bajaj-Elliott; P Fedeli; G V Smith; P Domizio; L Maher; R S Ali; A G Quinn; M J G Farthing
Journal:  Gut       Date:  2002-09       Impact factor: 23.059

7.  Probiotics and small bowel mucosa: Molecular aspects of their interactions.

Authors:  N Saulnier; M A Zocco; S Di Caro; G Gasbarrini; A Gasbarrini
Journal:  Genes Nutr       Date:  2006-06       Impact factor: 5.523

8.  Expression of human beta-defensins in conjunctival epithelium: relevance to dry eye disease.

Authors:  Srihari Narayanan; William L Miller; Alison M McDermott
Journal:  Invest Ophthalmol Vis Sci       Date:  2003-09       Impact factor: 4.799

9.  beta-Defensin-3 and -4 in intestinal epithelial cells display increased mRNA expression in ulcerative colitis.

Authors:  A Fahlgren; S Hammarstrom; A Danielsson; M-L Hammarstrom
Journal:  Clin Exp Immunol       Date:  2004-08       Impact factor: 4.330

10.  Expression of human beta-defensin 2 in human nasal mucosa.

Authors:  Po-Hsu Chen; Sheen-Yie Fang
Journal:  Eur Arch Otorhinolaryngol       Date:  2003-09-18       Impact factor: 2.503
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