| Literature DB >> 10947977 |
H Li1, S K Kolluri, J Gu, M I Dawson, X Cao, P D Hobbs, B Lin, G Chen, J Lu, F Lin, Z Xie, J A Fontana, J C Reed, X Zhang.
Abstract
TR3, an immediate-early response gene and an orphan member of the steroid-thyroid hormone-retinoid receptor superfamily of transcription factors, regulates apoptosis through an unknown mechanism. In response to apoptotic stimuli, TR3 translocates from the nucleus to mitochondria to induce cytochrome c release and apoptosis. Mitochondrial targeting of TR3, but not its DNA binding and transactivation, is essential for its proapoptotic effect. Our results reveal a mechanism by which a nuclear transcription factor translocates to mitochondria to initiate apoptosis.Entities:
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Year: 2000 PMID： 10947977 DOI： 10.1126/science.289.5482.1159
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728