Literature DB >> 10946140

Determination of the activity of ponazuril against Sarcocystis neurona in cell cultures.

D S Lindsay1, J P Dubey, T J Kennedy.   

Abstract

The present study examined the efficacy of ponazuril in inhibiting merozoite production of Sarcocystis neurona in cell cultures. Ponazuril inhibited merozoite production by more that 90% in cultures of S. neurona treated with 1.0 microg/ml ponazuril and greater than 95% inhibition of merozoite production was observed when infected cultures were treated with 5.0 microg/ml ponazuril. Ponazuril may have promise as a therapeutic agent in the treatment of S. neurona induced equine protozoal myeloencephalitis (EPM) in horses.

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Year:  2000        PMID： 10946140     DOI： 10.1016/s0304-4017(00)00280-6

Source DB:  PubMed          Journal:  Vet Parasitol        ISSN： 0304-4017            Impact factor:   2.738


  7 in total

1.  Ponazuril inhibits the development of Eimeria vermiformis in experimentally infected outbred Swiss mice.

Authors:  S A Billeter; J A Spencer; B Chobotar; B L Blagburn
Journal:  Parasitol Res       Date:  2004-12-23       Impact factor: 2.289

2.  Toltrazuril does not show an effect against pigeon protozoal encephalitis.

Authors:  Kristina Maier; P Olias; A D Gruber; M Lierz
Journal:  Parasitol Res       Date:  2015-02-04       Impact factor: 2.289

Review 3.  An update on Sarcocystis neurona infections in animals and equine protozoal myeloencephalitis (EPM).

Authors:  J P Dubey; D K Howe; M Furr; W J Saville; A E Marsh; S M Reed; M E Grigg
Journal:  Vet Parasitol       Date:  2015-02-07       Impact factor: 2.738

Review 4.  Equine Protozoal Myeloencephalitis: An Updated Consensus Statement with a Focus on Parasite Biology, Diagnosis, Treatment, and Prevention.

Authors:  S M Reed; M Furr; D K Howe; A L Johnson; R J MacKay; J K Morrow; N Pusterla; S Witonsky
Journal:  J Vet Intern Med       Date:  2016-02-09       Impact factor: 3.333

5.  Effects of coadministration of corn oil and ponazuril on serum and cerebrospinal fluid concentrations of ponazuril in horses.

Authors:  Martin Furr; Tom Kennedy
Journal:  J Vet Intern Med       Date:  2020-04-17       Impact factor: 3.333

6.  Pharmacokinetics of ponazuril after administration of a single oral dose to green turtles (Chelonia mydas).

Authors:  Elliott R Jacobson; Nicole I Stacy; Douglas R Mader; Richie Moretti; Bette Zirkelbach; Olivia Carlile; Courtney D O'Connor; Kaylin J Caperton; Lara K Maxwell
Journal:  Vet Q       Date:  2021-12       Impact factor: 3.320

7.  High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth.

Authors:  Gregory D Bowden; Kirkwood M Land; Roberta M O'Connor; Heather M Fritz
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2018-02-16       Impact factor: 4.077
  7 in total

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