BACKGROUND: The extent of premorbid changes associated with the onset of schizophrenia are debated. AIMS: The study examined cognitive and behavioural functioning prior to, and after, first hospitalisation for schizophrenia. METHOD: Data from the Israeli Draft Board Register of intelligence, social functioning and behaviour testing for all Israeli males aged 16-17 was linked with data from the National Psychiatric Hospitalisation Case Register. This identified 692 men who had been admitted to hospital for schizophrenia. Cases and non-cases matched on age and school were compared, as were cases aggregated by the time that had elapsed between testing and first admission to hospital. RESULTS: Cases performed worse than non-cases on all measures. On Social Functioning and on Raven's Progressive Matrices-R, differences between cases and non-cases were progressively greater for cases admitted closer to the time of testing. These differences were greatest for persons tested after first psychiatric hospitalisation. CONCLUSIONS: The results confirm premorbid deficits associated with schizophrenia and support the hypothesis that decline is progressive.
BACKGROUND: The extent of premorbid changes associated with the onset of schizophrenia are debated. AIMS: The study examined cognitive and behavioural functioning prior to, and after, first hospitalisation for schizophrenia. METHOD: Data from the Israeli Draft Board Register of intelligence, social functioning and behaviour testing for all Israeli males aged 16-17 was linked with data from the National Psychiatric Hospitalisation Case Register. This identified 692 men who had been admitted to hospital for schizophrenia. Cases and non-cases matched on age and school were compared, as were cases aggregated by the time that had elapsed between testing and first admission to hospital. RESULTS: Cases performed worse than non-cases on all measures. On Social Functioning and on Raven's Progressive Matrices-R, differences between cases and non-cases were progressively greater for cases admitted closer to the time of testing. These differences were greatest for persons tested after first psychiatric hospitalisation. CONCLUSIONS: The results confirm premorbid deficits associated with schizophrenia and support the hypothesis that decline is progressive.
Authors: Sarah I Tarbox; Jean Addington; Kristin S Cadenhead; Tyrone D Cannon; Barbara A Cornblatt; Diana O Perkins; Larry J Seidman; Ming T Tsuang; Elaine F Walker; Robert Heinssen; Thomas H McGlashan; Scott W Woods Journal: Psychiatry Res Date: 2013-10-18 Impact factor: 3.222
Authors: Kristen A Woodberry; William R McFarlane; Anthony J Giuliano; Mary B Verdi; William L Cook; Stephen V Faraone; Larry J Seidman Journal: Schizophr Res Date: 2013-02-22 Impact factor: 4.939
Authors: Caroline C Hilti; Tarik Delko; Ariane T Orosz; Kathrin Thomann; Stephan Ludewig; Mark A Geyer; Franz X Vollenweider; Joram Feldon; Katja Cattapan-Ludewig Journal: Neuropsychobiology Date: 2009-12-12 Impact factor: 2.328
Authors: V S Gabrovska-Johnson; M Scott; S Jeffries; N Thacker; R C Baldwin; A Burns; S W Lewis; J F W Deakin Journal: Psychopharmacology (Berl) Date: 2003-07-04 Impact factor: 4.530
Authors: Ingo Frommann; Ralf Pukrop; Jürgen Brinkmeyer; Andreas Bechdolf; Stephan Ruhrmann; Julia Berning; Petra Decker; Michael Riedel; Hans-Jürgen Möller; Wolfgang Wölwer; Wolfgang Gaebel; Joachim Klosterkötter; Wolfgang Maier; Michael Wagner Journal: Schizophr Bull Date: 2010-01-06 Impact factor: 9.306