Literature DB >> 10943628

Clarithromycin associated with torsades de pointes.

H Kamochi1, T Nii, K Eguchi, T Mori, A Yamamoto, K Shimoda, K Ibaraki.   

Abstract

Two cases of QT prolongation and torsades de pointes (TdP) are presented. The patients had been taking clarithromycin (400 mg/day) for respiratory disease. Although erythromycin is reportedly associated with TdP, this is the first report of clarithromycin associated with TdP in the absence of other drugs already known to produce QT prolongation.

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Year:  1999        PMID： 10943628     DOI： 10.1253/jcj.63.421

Source DB:  PubMed          Journal:  Jpn Circ J        ISSN： 0047-1828


  8 in total

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Journal:  Drug Saf       Date:  2001       Impact factor: 5.606

2.  Prediction of the risk of Torsade de Pointes using the model of isolated canine Purkinje fibres.

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3.  Characterization of the inhibitory effects of erythromycin and clarithromycin on the HERG potassium channel.

Authors:  Scott J C Stanat; Carol G Carlton; William J Crumb; Krishna C Agrawal; Craig W Clarkson
Journal:  Mol Cell Biochem       Date:  2003-12       Impact factor: 3.396

Review 4.  QT prolongation with antimicrobial agents: understanding the significance.

Authors:  Robert C Owens
Journal:  Drugs       Date:  2004       Impact factor: 9.546

5.  Clarithromycin, QTc interval prolongation and torsades de pointes: the need to study case reports.

Authors:  W Victor R Vieweg; Jules C Hancox; Mehrul Hasnain; Jayanthi N Koneru; Michael Gysel; Adrian Baranchuk
Journal:  Ther Adv Infect Dis       Date:  2013-08

Review 6.  Macrolide antibiotics and the risk of cardiac arrhythmias.

Authors:  Richard K Albert; Joseph L Schuller
Journal:  Am J Respir Crit Care Med       Date:  2014-05-15       Impact factor: 21.405

7.  Use of clarithromycin and roxithromycin and risk of cardiac death: cohort study.

Authors:  Henrik Svanström; Björn Pasternak; Anders Hviid
Journal:  BMJ       Date:  2014-08-19

8.  Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk.

Authors:  Nathalie Nguyen; William Nguyen; Brynna Nguyenton; Phachareeya Ratchada; Guy Page; Paul E Miller; Andre Ghetti; Najah Abi-Gerges
Journal:  Front Physiol       Date:  2017-12-19       Impact factor: 4.566
  8 in total

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