| Literature DB >> 10941194 |
G B Stefano1, Y Goumon, F Casares, P Cadet, G L Fricchione, C Rialas, D Peter, D Sonetti, M Guarna, I D Welters, E Bianchi.
Abstract
It is now well accepted that endogenous morphine is present in animals, both in invertebrates and vertebrates. It is a key signaling molecule that plays an important role in downregulating physiological responses, such as those in the immune system, including immune elements in the CNS. It has been demonstrated that a specific mu-opiate-receptor subtype, mu3, mediates these downregulatory effects through release of NO. This article examines morphine as an endogenous signaling molecule, in terms of its role in neural and immune regulation.Entities:
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Year: 2000 PMID： 10941194 DOI： 10.1016/s0166-2236(00)01611-8
Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837