Literature DB >> 10940812

The pig as an experimental animal model of percutaneous permeation in man: qualitative and quantitative observations--an overview.

G A Simon1, H I Maibach.   

Abstract

The pig has been a well-recognized experimental animal in biomedical research for many centuries. Physiological and anatomical similarities between man and pig made this animal a good model for man in many research areas. Pharmacological and toxicological research on the skin is often based on knowledge of skin absorption and percutaneous permeation. Anatomical, physiological and biochemical similarities are cited and various uses of the pig as a model for man in the investigation of skin permeation are reviewed. Further, several isolated organ models are reviewed. The importance of full details of the experimental animal, namely its age, sex, breed, size (weight) and body region, is emphasized. Copyright 2000 S. Karger AG, Basel.

Entities:  

Mesh：

Year:  2000        PMID： 10940812     DOI： 10.1159/000029928

Source DB:  PubMed          Journal:  Skin Pharmacol Appl Skin Physiol        ISSN： 1422-2868


  50 in total

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5.  Topical delivery of a naproxen-dithranol co-drug: in vitro skin penetration, permeation, and staining.

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7.  In Silico Estimation of Skin Concentration Following the Dermal Exposure to Chemicals.

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8.  Microneedle-assisted percutaneous delivery of naltrexone hydrochloride in yucatan minipig: in vitro-in vivo correlation.

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9.  Functional Testing of a Skin Topical Formulation In Vivo: Objective and Quantitative Evaluation in Human Skin Scarring Using a Double-Blind Volunteer Study with Sequential Punch Biopsies.

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10.  Neuro-muscular differentiation of adult porcine skin derived stem cell-like cells.

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