| Literature DB >> 10940519 |
B F Bishop1, C I Bruce, N A Evans, A C Goudie, K A Gration, S P Gibson, M S Pacey, D A Perry, N D Walshe, M J Witty.
Abstract
Selamectin, 25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22, 23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide, is a novel endectocide with a unique combination of efficacy and safety in dogs and cats following both oral and topical administration. The compound is active against fleas and ticks, intestinal hookworms and ascarids, and immature heartworms. Also it is well tolerated at higher dosages than 22,23-dihydroavermectin B1a (DHAVM) or milbemycin oxime in Collies, which is a breed known to exhibit idiosyncratic sensitivity to avermectins.Entities:
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Year: 2000 PMID： 10940519 DOI： 10.1016/s0304-4017(00)00289-2
Source DB: PubMed Journal: Vet Parasitol ISSN： 0304-4017 Impact factor: 2.738